Evidence map›Paper›PMID 23292287›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2013

Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults.

Anthony P Marsh, M Kyla Shea, Rachel M Vance Locke, Michael E Miller, Scott Isom, Gary D Miller, Barbara J Nicklas, Mary F Lyles, Jeffery J Carr, Stephen B Kritchevsky

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  5. Community Weight Loss to Combat Obesity and Disability in At-Risk Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
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  17. Emerging molecular mediators and targets for age-related skeletal muscle atrophy.Translational research : the journal of laboratory and clinical medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anthony P MarshDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109-7868, USA. marshap@wfu.edu
M Kyla Shea
Rachel M Vance Locke
Michael E Miller
Scott Isom
Gary D Miller
Barbara J Nicklas
Mary F Lyles
Jeffery J Carr
Stephen B Kritchevsky
Wake Forest University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG028740NIA NIH HHS P30-AG21332
6 · The paper itself

Abstract

backgroundThe prevalence of obesity in older adults is increasing but concerns exist about the effect of weight loss on muscle function. Demonstrating that muscle strength and power are not adversely affected during "intentional" weight loss in older adults is important given the wide-ranging negative health effects of excess adiposity.

methodsParticipants (N = 88; age = 70.6 ± 3.6 years; body mass index = 32.8 ± 4.5 kg/m(2)) were randomly assigned to one of four intervention groups: pioglitazone or placebo and resistance training (RT) or no RT, while undergoing intentional weight loss via a hypocaloric diet. Outcomes were leg press power and isometric knee extensor strength. Analysis of covariance, controlling for baseline values, compared follow-up means of power and strength according to randomized groups.

resultsParticipants lost an average of 6.6% of initial body mass, and significant declines were observed in fat mass, lean body mass, and appendicular lean body mass. Compared with women not randomized to RT, women randomized to RT had significant improvements in leg press power (p < .001) but not in knee extensor strength (p = 0.12). No significant differences between groups in change in power or strength from baseline were detected in men (both p > .25). A significant pioglitazone-by-RT interaction for leg press power was detected in women (p = .006) but not in men (p = .88).

conclusionsIn older overweight and obese adults, a hypocaloric weight loss intervention led to significant declines in lean body mass and appendicular lean body mass. However, in women assigned to RT, leg power significantly improved following the intervention, and muscle strength or power was not adversely effected in the other groups. Pioglitazone potentiated the effect of RT on muscle power in women but not in men; mechanisms underlying this sex effect remain to be determined.

Indexed as

AgingMuscle StrengthResistance TrainingWeight LossAgedBody CompositionBody Mass IndexFemaleFollow-Up StudiesHumansHypoglycemic AgentsMaleObesityOverweightPioglitazoneSingle-Blind MethodHypoglycemic AgentsPioglitazoneThiazolidinedionesMuscle powerMuscle strengthObesityResistance trainingVoluntary weight loss.

Identifiers

PMID23292287
PMCPMC3693600
OpenAlexW2149965016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.