Trial reportBone marrow transplantation2013
Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT.
Trial report in Bone marrow transplantation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between dry mouth and dry eyes: a systematic literature review of clinical evidence.Rheumatology international · 2025Pooled it
- The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Hyposalivation and salivary gland histopathology in graft-versus-host disease.Frontiers in oral health · 2026Article
- Interplay of salivary function, oral health, and psychological well-being in hematopoietic stem cell transplantation: a longitudinal cohort study.Clinical oral investigations · 2025Article
- Minor Salivary Gland Biopsy in the Differential Diagnosis of Sicca Syndrome: A Monocentric Cohort Analysis.International journal of molecular sciences · 2025Article
- Oral Health-Related Quality of Life After Allogeneic Bone Marrow Transplant-A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Salivary flow rate, subjective oral dryness and dental caries 5 years after haematopoietic cell transplantation.BMC oral health · 2024Observational
- Periodontal diseases, caries, and dental abscesses prevalence in hematopoietic stem cell transplant recipients.Bone marrow transplantation · 2021Article
- Oral disorders in patients with newly diagnosed haematological diseases.Clinical oral investigations · 2020Article
- Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation.PloS one · 2019Article
- Determinants of stimulated salivary flow among haematopoietic stem cell transplantation recipients.Clinical oral investigations · 2017Article
- Assessing the relationship between oral chronic graft-versus-host disease and global measures of quality of life.Oral oncology · 2015Article
- Clinical approach in the management of oral chronic graft-versus-host disease (cGVHD) in a series of specialized medical centers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Symptom distress predicts long-term health and well-being in allogeneic stem cell transplantation survivors.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2014Article
- Oral complications in hematopoietic stem cell recipients: the role of inflammation.Mediators of inflammation · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this prospective cross-sectional case-control study was to examine the prevalence of dryness symptoms and its impact on quality of life (QoL) among very long-term survivors after hematopoietic SCT (HSCT) in comparison with their respective sibling donors. Forty-four allogeneic HSCT recipients with a long-term survival (median: 17.5; range: 11-26 years) were included. Their respective, HLA-identical sibling donors served as controls. Clinical examinations included saliva flow rates (SFR) and the Schirmer's test. The presence of sicca symptoms of mouth, eyes and skin were inquired. The social functioning (SF)-36 questionnaire was applied. Recipients had lower (P<0.01) unstimulated and stimulated mean SFR than donors. Schirmer's test results <5 mm was found in 45% of the recipients in comparison with 27% of the donors (P = 0.07). Xerostomia (34 vs 4 subjects), xerophtalmia (23 vs 3) and dry skin (32 vs 12) were reported more often by the recipients than donors (P<0.001). Sicca symptoms and their objective findings correlated with QoL. The mean SF-36 scores of the donors were significantly higher than those of the recipients for physical component summary. In conclusion, sicca symptoms are common amongst long-term survivors of HSCT and affect remarkably the QoL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.