ArticleRheumatology international2013
A SMAD3 gene polymorphism is related with osteoarthritis in a Northeast Chinese population.
Article in Rheumatology international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2018Pooled it
- Pooled it
- SMAD3 Gene Polymorphisms and Protein Expression as Potential Biomarkers of Susceptibility to Knee Osteoarthritis.Cureus · 2026Article
- The polymorphism of SMAD3 rs1065080 is associated with increased risk for knee osteoarthritis.Molecular biology reports · 2019Article
- Association between SMAD3 gene rs12901499 polymorphism and knee osteoarthritis in a Chinese population.Journal of clinical laboratory analysis · 2018Article
- Genetic variation of SMAD3 is associated with hip osteoarthritis in a Chinese Han population.The Journal of international medical research · 2018Article
- The association between rs12901499 polymorphism in SMAD3 gene and risk of osteoarthritis: a meta-analysis.Therapeutics and clinical risk management · 2018Article
- Association study of candidate genes for susceptibility to Kashin-Beck disease in a Tibetan population.BMC medical genetics · 2017Article
- Article
- Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty.Drugs & aging · 2015Review
- Gene-gene interactions between TGF-β/Smad3 signalling pathway polymorphisms affect susceptibility to knee osteoarthritis.BMJ open · 2015Article
- Association of the Smad3 and NFATc2 gene polymorphisms and their serum levels with susceptibility to rheumatoid arthritis in Polish cohorts.Clinical and experimental immunology · 2015Article
- Characterization of SMAD3 Gene Variants for Possible Roles in Ventricular Septal Defects and Other Congenital Heart Diseases.PloS one · 2015Article
- Characterization of Transcriptional Repressor Gene MSX1 Variations for Possible Associations with Congenital Heart Diseases.PloS one · 2015Article
- SMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study.PloS one · 2014Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variants in the SMAD family member 3 (SMAD3) have recently been reported to be associated with osteoarthritis (OA) in European populations. However, the results are contestable. To assess the role of such variants in SMAD3 in OA susceptibility in peripheral joints OA, we conducted a case-control study in a Northeast Chinese population. The SMAD3 SNP was genotyped in patients who had primary symptomatic OA with radiographic confirmation and clinical symptom and in controls, and the associations were examined. A total of 111 knee OA patients, 121 hand OA patients and 236 controls were genotyped. Statistically significant difference was detected in genotype and allele frequencies between OA and control groups in the population. There were significant association for knee OA OR = 3.68 (95 % CI 2.03-6.70; p < 0.001) and for hand OA OR = 3.60 (95 % CI 2.01, 6.44; p < 0.001). The association was also positive even after stratification by sex except for male population of knee OA. Our data indicated that genetic variation in the SMAD3 gene is involved in pathogenesis of both knee OA and hand OA in Northeast Chinese population, which is consistent with in European populations.
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