ArticleGenome biology and evolution2013
Comparative genomics of odorant binding proteins in Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 158 citations in OpenAlex.
- Genome-wide identification of olfactory receptor and odorant-binding protein gene families and their roles in Heliothine chemosensory evolution.Insect molecular biology · 2026Article
- Methodology for the Analysis of Odorant-Binding Proteins in Asiatic Genetic Groups of Bemisia tabaci.Biochemical genetics · 2026Article
- Odorant-binding proteins and chemosensory proteins in insects: structural insights, functional plasticity, and prospects for targeted pest management.Molecular biology reports · 2026Review
- Genome-Wide Identification and Comparative Characterization of Chemosensory Gene Families in TwoInsects · 2026Article
- A Safer Alternative Bio-Repellent: Targeting Mosquito Odorant-Binding Proteins with Catnip-Derived Nepetalactones fromInternational journal of molecular sciences · 2026Article
- Article
- Characterization of odorant binding and chemosensory protein families in the kissing bug Triatoma infestans: comparative analysis among Heteroptera species.BMC genomics · 2025Article
- Omics Approaches in Understanding Insecticide Resistance in Mosquito Vectors.International journal of molecular sciences · 2025Review
- Genome-Wide Identification and Expression Profiling of Odorant-Binding Protein Genes in the Bean Flower ThripsInsects · 2025Article
- The chromosome-scale genome assembly for the West Nile vector Culex quinquefasciatus uncovers patterns of genome evolution in mosquitoes.BMC biology · 2024Article
- Identification and odor exposure regulation of odorant-binding proteins inFrontiers in physiology · 2024Article
- Characterization of the ligand-binding properties of odorant-binding protein 38 fromFrontiers in physiology · 2024Article
- Article
- iOBPdb A Database for Experimentally Determined Functional Characterization of Insect Odorant Binding Proteins.Scientific data · 2023Article
- Genome-wide identification and characterization of the chemosensory relative protein genes in Rhus gall aphid Schlechtendalia chinensis.BMC genomics · 2023Article
- A draft Diabrotica virgifera virgifera genome: insights into control and host plant adaption by a major maize pest insect.BMC genomics · 2023Article
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
- Identification and expression profile analysis of chemosensory genes in pine needle gall midge,Frontiers in physiology · 2023Article
- An Overview of D7 Protein Structure and Physiological Roles in Blood-Feeding Nematocera.Biology · 2022Review
- Mosquito host-seeking diel rhythm and chemosensory gene expression is affected by age and Plasmodium stages.Scientific reports · 2022Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About 1 million people in the world die each year from diseases spread by mosquitoes, and understanding the mechanism of host identification by the mosquitoes through olfaction is at stake. The role of odorant binding proteins (OBPs) in the primary molecular events of olfaction in mosquitoes is becoming an important focus of biological research in this area. Here, we present a comprehensive comparative genomics study of OBPs in the three disease-transmitting mosquito species Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus starting with the identification of 110 new OBPs in these three genomes. We have characterized their genomic distribution and orthologous and phylogenetic relationships. The diversity and expansion observed with respect to the Aedes and Culex genomes suggests that the OBP gene family acquired functional diversity concurrently with functional constraints posed on these two species. Sequences with unique features have been characterized such as the "two-domain OBPs" (previously known as Atypical OBPs) and "MinusC OBPs" in mosquito genomes. The extensive comparative genomics featured in this work hence provides useful primary insights into the role of OBPs in the molecular adaptations of mosquito olfactory system and could provide more clues for the identification of potential targets for insect repellants and attractants.
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