ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2013
Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02837367 (Use of Nutrigenomic Models for the Personalized Treatment With Medical Foods in Obese People), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Nutrigenomic Models for the Personalized Treatment With Medical Foods in Obese People
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Racial and Ethnic Disparities in Nonalcoholic Fatty Liver Disease Prevalence, Severity, and Outcomes in the United States: A Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018Pooled it
- Plasma Lipid Metabolites Differentiate Metabolic From Viral Chronic Liver Disease.The Journal of infectious diseases · 2025Article
- Common genetic polymorphisms define one-carbon metabolite responses to different forms of choline in healthy adult males.Frontiers in nutrition · 2025Article
- Cellular and organismal function of choline metabolism.Nature metabolism · 2025Review
- Metabolic liver cancer: associations of rare and common germline variants in one-carbon metabolism and DNA methylation genes.Human molecular genetics · 2023Article
- Serum Metabolites Are Associated With HFpEF in Biopsy-Proven Nonalcoholic Fatty Liver Disease.Journal of the American Heart Association · 2023Article
- Nutritional Genomics in Nonalcoholic Fatty Liver Disease.Biomedicines · 2023Review
- NAFLD in normal weight individuals.Diabetology & metabolic syndrome · 2022Review
- Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota.European journal of nutrition · 2021Review
- The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease.Metabolism: clinical and experimental · 2020Review
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice.Scientific reports · 2020Article
- Article
- Single Nucleotide Polymorphisms inNutrients · 2019Article
- A Conceptual Framework for Studying and Investing in Precision Nutrition.Frontiers in genetics · 2019Article
- Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Genome-Wide Association Study for Muscle Fat Content and Abdominal Fat Traits in Common Carp (Cyprinus carpio).PloS one · 2016Article
- Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Systematic review of genetic association studies involving histologically confirmed non-alcoholic fatty liver disease.BMJ open gastroenterology · 2015Article
- Higher dietary choline intake is associated with lower risk of nonalcoholic fatty liver in normal-weight Chinese women.The Journal of nutrition · 2014Article
- Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Choline metabolism is important for very low-density lipoprotein secretion, making this nutritional pathway an important contributor to hepatic lipid balance. The purpose of this study was to assess whether the cumulative effects of multiple single nucleotide polymorphisms (SNPs) across genes of choline/1-carbon metabolism and functionally related pathways increase susceptibility to developing hepatic steatosis. In biopsy-characterized cases of nonalcoholic fatty liver disease and controls, we assessed 260 SNPs across 21 genes in choline/1-carbon metabolism. When SNPs were examined individually, using logistic regression, we only identified a single SNP (PNPLA3 rs738409) that was significantly associated with severity of hepatic steatosis after adjusting for confounders and multiple comparisons (P=0.02). However, when groupings of SNPs in similar metabolic pathways were defined using unsupervised hierarchical clustering, we identified groups of subjects with shared SNP signatures that were significantly correlated with steatosis burden (P=0.0002). The lowest and highest steatosis clusters could also be differentiated by ethnicity. However, unique SNP patterns defined steatosis burden irrespective of ethnicity. Our results suggest that analysis of SNP patterns in genes of choline/1-carbon metabolism may be useful for prediction of severity of steatosis in specific subsets of people, and the metabolic inefficiencies caused by these SNPs should be examined further.
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