ArticleVirchows Archiv : an international journal of pathology2013
A significant imbalance in mitosis versus apoptosis accelerates the growth rate of sessile serrated adenoma/polyps.
Article in Virchows Archiv : an international journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Proliferation, apoptosis and their regulatory protein expression in colorectal adenomas and serrated lesions.PloS one · 2021Article
- Correlations of morphology and molecular alterations in traditional serrated adenoma.World journal of gastrointestinal pathophysiology · 2020Review
- Serrated Polyps of Colon and Rectum: a Clinicopathologic Review.Journal of gastrointestinal cancer · 2017Review
- A case of inflammatory hepatocellular adenoma displaying an unusual histological pattern.Clinical journal of gastroenterology · 2015Article
- Sessile serrated adenomas versus conventional adenomas. Different polyps in different populations?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Article
- Claudin-1 Expression Is Elevated in Colorectal Cancer Precursor Lesions Harboring the BRAF V600E Mutation.Translational oncology · 2014Article
- Serrated polyps of right colon: guilty or innocent?Annals of gastroenterology · 2013Review
- Apoptosis and expression of argyrophilic nucleolus organizer regions in epithelial neoplasms of the larynx.Brazilian journal of otorhinolaryngologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sessile serrated adenoma/polyps (SSA/Ps) of the colon are thought to be precursors of sporadic carcinomas. Although it is suggested that SSA/P may grow rapidly from the early stage, its cell kinetics remains obscure. To solve this problem, we analyzed the mitotic and apoptotic activity of normal crypts, microvesicular hyperplastic polyps (MVHPs), and tubular adenomas (TAs), using phospho-histone H3 and cleaved caspase 3 immunohistochemistry. The mitotic index for SSA/Ps (mean, 5.63) and TAs (6.98) was significantly higher than those for normal crypts (2.72) and MVHPs (2.86). Of all tested lesions, the apoptotic index was lowest for SSA/Ps (0.96; normal, 2.71; MVHPs, 2.62; TAs, 6.01) with statistically significant differences. The net growth ratio was close to 1.0 in normal crypts (1.07) while remaining low in MVHPs (1.06) and TAs (1.38), but was markedly elevated in SSA/Ps (7.32, P < 0.01) due to the large imbalance between mitosis and apoptosis. As to apoptosis regulatory proteins, expression of anti-apoptotic Bcl-2 was significantly reduced or undetectable in MVHPs and SSA/Ps, while TAs showed stronger staining than normal crypts. Expression of pro-apoptotic Bax and its activators, Bim and Bad, was significantly reduced in MVHPs and SSA/Ps. We suggest that other complex mechanisms may act synergistically with Bax, Bim, or Bad deficiency to regulate apoptosis suppression in SSA/Ps.
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