Trial reportLasers in medical science2014
Esthetic treatment of gingival hyperpigmentation with Nd:YAG laser or scalpel technique: a 6-month RCT of patient and professional assessment.
Trial report in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- "Laser assisted gingival melanin depigmentation using diode 450 nm; ablative vs. non-ablative techniques: randomized clinical trial".Lasers in medical science · 2025Trial
- Efficacy of different gingival graft de-epithelialization methods: A parallel-group randomized clinical trial.Clinical oral investigations · 2025Trial
- Gingival depigmentation with diode and Er,Cr:YSGG laser: evaluating re-pigmentation rate and patient perceptions.Clinical oral investigations · 2021Trial
- Management of Physiological Gingival Pigmentation Using Two Treatment Modalities: Clinical and Patient-Reported Outcomes.Maedica · 2025Article
- CIELab Colour Coordinate Changes Associated with the Resolution of Gingival Inflammation: Influence of Biotype and Severity.Journal of clinical medicine · 2025Article
- Evaluation of pain during gingival depigmentation using diode laser and conventional scalpel technique.Bioinformation · 2025Article
- A Comparative Study of the Use of a 980 nm Diode Laser and 10600nm CO2 in the Treatment of Gingival Melanin Pigmentation.Journal of lasers in medical sciences · 2024Article
- Efficacy and Risks of Different Treatments for Oral Hyperpigmentation: A Systematic Review and Network Meta-Analysis.Journal of clinical medicine · 2023Review
- Aesthetic Gingival Melanin Pigmentation Treatment in Smokers and Non-Smokers: A Comparison Study Using Nd:YAG Laser and Ceramic Bur.Journal of personalized medicine · 2023Article
- Transepithelial Gingival Depigmentation Using a New Protocol with Q-Switched Nd:YAG: An In Vivo Observational Study.Dentistry journal · 2022Article
- Evaluation of Carbon Dioxide Laser-Assisted Treatment for Gingival Melanin Hyperpigmentation.Dentistry journal · 2022Article
- Comparison of the Effectiveness of CO2 and Diode Lasers for Gingival Melanin Depigmentation: A Randomized Clinical Trial.Journal of lasers in medical sciences · 2022Article
- Long-Term Esthetically Depigmented Gingiva in a Short Operative Duration, Using Two Modes of 940 nm Diode Lasers-A Randomized Clinical Trial.International journal of dentistry · 2022Article
- Comparison of Bur Abrasion and CO2 Laser in Treatment of Gingival Pigmentation: 6 Months Follow-Up.Oral health & preventive dentistry · 2021Article
- Laser-Assisted Depigmentation-An Introspection of the Science, Techniques, and Perceptions.Dentistry journal · 2020Review
- Laser Treatment for Melanin Gingival Pigmentations: A Comparison Study for 3 Laser Wavelengths 2780, 940, and 445 nm.International journal of dentistry · 2020Article
- A Comparison of 940 nm Diode Laser and Cryosurgery With Liquid Nitrogen in the Treatment of Gingival Physiologic Hyperpigmentation Using Split Mouth Technique: 12 Months Follow Up.Journal of lasers in medical sciences · 2019Article
- Laser Surgery of Soft Tissue in Orthodontics: Review of the Clinical Trials.Journal of lasers in medical sciences · 2017Review
- A Split Mouth Randomized Clinical Comparative Study to Evaluate the Efficacy of Gingival Depigmentation Procedure Using Conventional Scalpel Technique or Diode Laser.Journal of lasers in medical sciences · 2016Article
- Lasers in esthetic treatment of gingival melanin hyperpigmentation: a review article.Lasers in medical science · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This double-masked, randomized controlled trial with a split-mouth design aimed to compare patient- and professional-centered outcomes using different therapeutic approaches-neodymium-yttrium aluminum garnet (Nd:YAG) laser or scalpel technique-for gingival depigmentation. Patients presenting bilateral melanin gingival hyperpigmentation and who requested cosmetic therapy were recruited. Contralateral quadrants were randomly assigned to receive Nd:YAG laser (settings: 6 W, 60 mJ/pulse, and 100 Hz) or scalpel technique. Patient morbidity experienced at intratherapy and during the first postoperative week was evaluated. In addition, after 6 months, the cosmetic results achieved for the different therapeutic approaches were evaluated by patients and professionals. The chair time of each technique was also calculated. Patient-oriented outcomes concerning intratherapy morbidity did not demonstrate any differences between groups (p > 0.05), although a higher extent of discomfort/pain was experienced in the side treated by the scalpel technique compared to the Nd:YAG laser procedure during the first posttherapy week (p < 0.05). Regarding to cosmetic outcomes, no differences between techniques were observed for patient and professionals (p > 0.05). Significantly higher chair time was required for the scalpel technique than for the Nd:YAG laser therapy (p < 0.05). The Nd:YAG laser or the scalpel technique may be successfully used for the treatment of melanin gingival hyperpigmentation. However, the use of the Nd:YAG laser has presented advantages in terms of less discomfort/pain during the posttherapy period and a reduction of treatment chair time.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.