Evidence map›Paper›PMID 23291880›Full record

ArticleLasers in medical science2013

ST36 laser acupuncture reduces pain-related behavior in rats: involvement of the opioidergic and serotonergic systems.

Vanessa Erthal, Morgana Duarte da Silva, Francisco J Cidral-Filho, Adair Roberto Soares Santos, Percy Nohama

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02522403 (Application of Laser Acupuncture in Rehabilitating Patients With Distal Radius Fracture), which is not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02522403 nacompletednot on this mapstarted 2015, after this paper: background citation

Application of Laser Acupuncture in Rehabilitating Patients With Distal Radius Fracture

TypeinterventionalSponsorUniversidad Autonoma de Nuevo LeonRan2015 to 2016Enrolled36ConditionsColles´ Fracture, Radius FractureArmsRehabilitation, Low Lever Laser acupuncture
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  17. The Application of Laser Acupuncture in Animal Experiments: A Narrative Review of Biological Aspects.Evidence-based complementary and alternative medicine : eCAM · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vanessa ErthalPrograma de Pós-Graduação em Tecnologia em Saúde, Pontifícia Universidade Católica do Paraná (PUCPR), Rua Imaculada Conceição, 1155, Curitiba, 80215-901, Paraná, Brazil.
Morgana Duarte da Silva
Francisco J Cidral-Filho
Adair Roberto Soares Santos
Percy Nohama
Universidade Federal de Santa Catarina · BRPontifícia Universidade Católica do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laser acupuncture is a modality of low-level light therapy used as an alternative to needling for the past three decades. Although it has proved effective for the treatment of various conditions, the mechanisms underlying its effects are not fully understood. To contribute to this understanding, this study was designed to (1) evaluate the antinociceptive effect of ST36 laser acupuncture (830 nm, 3 J/cm(2)) in rat models of acute nociception and (2) to investigate the opioidergic and serotonergic systems involvement in this effect. Our results demonstrate that ST36 laser acupuncture inhibited (36 ± 2 %) acetic acid-induced abdominal constrictions and both neurogenic (48 ± 7 %) and inflammatory (phase IIA 42 ± 8 % and phase IIB 83 ± 6 %) phases of formalin-induced nociceptive behavior. Moreover, the antinociceptive activity of laser irradiation in the acetic acid test was significantly reversed by preadministration of naloxone (1 mg/kg, nonselective opioid receptor antagonist), pindolol (1 mg/kg, subcutaneous; nonselective 5-HT 1A/B receptor antagonist), and ketanserin (1 mg/kg; selective 5-HT2A receptor antagonist) but not by ondansetron (1 mg/kg, selective 5-HT3 receptor antagonist). Taken together, our data demonstrate, for the first time, that (1) ST36 laser acupuncture elicited significant antinociceptive effect against acetic acid- and formalin-induced behavior in rats and that (2) this effect is mediated by activation of the opioidergic and serotonergic (5-HT1 and 5-HT2A receptors) systems.

Indexed as

Acupuncture AnalgesiaAnimalsDisease Models, AnimalLasers, SemiconductorLow-Level Light TherapyMaleNarcotic AntagonistsOpioid PeptidesPainPain ManagementRatsRats, WistarSerotoninSerotonin AntagonistsNarcotic AntagonistsOpioid PeptidesSerotoninSerotonin Antagonists

Identifiers

PMID23291880
OpenAlexW2078032933

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.