ArticleEuropean journal of nutrition2013
Maternal caffeine administration leads to adverse effects on adult mice offspring.
Article in European journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Novel Insights on Dietary Polyphenols for Prevention in Early-Life Origins of Hypertension: A Review Focusing on Preclinical Animal Models.International journal of molecular sciences · 2022Review
- Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin.Antioxidants (Basel, Switzerland) · 2022Review
- Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models.Biomedicines · 2022Review
- Prenatal Exposure to Methamphetamine Causes Vascular Dysfunction in Adult Male Rat Offspring.Frontiers in cardiovascular medicine · 2022Article
- Animal Models for DOHaD Research: Focus on Hypertension of Developmental Origins.Biomedicines · 2021Review
- Targeting the Renin-Angiotensin-Aldosterone System to Prevent Hypertension and Kidney Disease of Developmental Origins.International journal of molecular sciences · 2021Review
- Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?Frontiers in cardiovascular medicine · 2021Review
- In Utero Caffeine Exposure Induces Transgenerational Effects on the Adult Heart.Scientific reports · 2016Article
- Caffeine and cardiovascular diseases: critical review of current research.European journal of nutrition · 2016Review
- Chronic fetal exposure to caffeine altered resistance vessel functions via RyRs-BKCa down-regulation in rat offspring.Scientific reports · 2015Article
- Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to evaluate the role of caffeine chronic administration during gestation of C57BL/6 mice on cardiac remodeling and the expression of components of the renin-angiotensin system (RAS) in male offspring as adults.
methodsPregnant C57BL/6 female mice were divided into two groups (n = 10): Control group (C), dams were injected with the vehicle only (saline 0.9% NaCl); Caffeine group (CF), dams received daily a subcutaneous injection of 20 mg/kg of caffeine/day (1 mg/mL saline). Pups had free access to standard chow since weaning to 3 months of age, when they were killed.
resultsCF group showed increased energy expenditure (+7%) with consequent reduction in body mass (BM) gain (-18%), increased blood pressure (+48%), and higher heart rate (+10%) than C group. The ratio between LV mass/BM was greater (+10%), with bigger cardiomyocytes (+40%), and reduced vascularization (-25%) in CF group than in C group. In the LV, the expression of angiotensin-converting enzyme (+30%), Angiotensin II (AngII) (+60%), AngII receptor (ATR)-1 (+77%) were higher, and the expression of ATR-2 was lower (-46%; P < 0.05) in CF group than in C group. In the kidney, the expressions of renin (+128%) and ATR-1 (+88%) were higher in CF group than in C group.
conclusionsChronic administration of caffeine to pregnant dams led to persistent activation of local RAS in the kidney and heart of the offspring, which, in turn, leads to high BP and adverse cardiac remodeling. These findings highlight the urge to encourage pregnant women to avoid food or medicines containing caffeine.
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Registered trials
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