ArticleMedical science monitor : international medical journal of experimental and clinical research2013
Zinc, copper, and blood pressure: Human population studies.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Blood trace element concentrations and adult hypertension: A systematic review and meta-analysis of observational studies.Environmental science and pollution research international · 2026Pooled it
- Blood copper and risk of cardiometabolic diseases: a Mendelian randomization study.Human molecular genetics · 2022Pooled it
- The effect of zinc supplementation on blood pressure: a systematic review and dose-response meta-analysis of randomized-controlled trials.European journal of nutrition · 2020Pooled it
- Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?Nutrients · 2019Trial
- Trial
- Association Between Zinc-to-Copper Ratio and Hypertension in Populations with Differential Environmental Heavy Metal Exposure.Biological trace element research · 2026Article
- A Comparison of Machine Learning Algorithms for Predicting Hypertension Incidence Based on Cohort Study.Endocrinology, diabetes & metabolism · 2026Article
- Relationship Between Urinary Copper, Zinc, and Cadmium and Kidney Damage Biomarkers in Young People.International journal of molecular sciences · 2025Article
- A cross-sectional analysis of the PURE study on minerals intake among Malaysian adult population with hypertension.Scientific reports · 2024Article
- Downregulation of inflammatory erectile dysfunction byToxicology reports · 2023Article
- Association of multi-metals with the risk of hypertension and the interaction with obesity: A cross-sectional study in China.Frontiers in public health · 2023Article
- Benefits and risks of essential trace elements in chronic kidney disease: a narrative review.Annals of translational medicine · 2022Review
- Association of zinc serum level with metabolic syndrome in iranian children and adolescents: The CASPIAN-V study.Frontiers in nutrition · 2022Article
- Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis.Nutrients · 2021Review
- Ambient Particle Components and Newborn Blood Pressure in Project Viva.Journal of the American Heart Association · 2021Article
- Selenium, copper, zinc and hypertension: an analysis of the National Health and Nutrition Examination Survey (2011-2016).BMC cardiovascular disorders · 2020Article
- Evolutionarily derived networks to inform disease pathways.Genetic epidemiology · 2017Article
- Relationships between micronutrient losses in sweat and blood pressure among heat-exposed steelworkers.Industrial health · 2016Article
- Relationship between the concentrations of heavy metals and bioelements in aging men with metabolic syndrome.International journal of environmental research and public health · 2015Article
- Atomic absorption spectrometry analysis of trace elements in degenerated intervertebral disc tissue.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Copper and zinc are essential trace biometals that regulate cardiovascular homeostasis, and dysregulation of these metals has been linked to vascular diseases, including hypertension. In this article, we review recent human population studies concerning this topic, focusing on: 1) the relationship between blood pressure and levels of zinc and copper; 2) correlations between trace metals, the renin-angiotensin system, obesity, and hypertension; 3) the relationship between environmental metal pollution and the development of hypertension; and 4) methods commonly employed to assay zinc and copper in human specimens. Moreover, based on the findings of these studies, we suggest the following topics as the basis for future investigations: 1) the potential role of environmental metal pollution as a causal factor for hypertension; 2) metal profiles within specific pathogenic subsets of patients with hypertension; 3) standardizing the experimental design so that the results between different studies are more comparable; and 4) the requirement for animal experiments as complementary approaches to address mechanistic insight that cannot be studied in human populations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.