ArticleEukaryotic cell2013
Complete genome sequences from three genetically distinct strains reveal high intraspecies genetic diversity in the microsporidian Encephalitozoon cuniculi.
Article in Eukaryotic cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Encephalitozoonosis in Pet Rabbits: Epidemiology, Pathogenesis, Immunology and Consensus on Clinical Management.Animals : an open access journal from MDPI · 2026Review
- In vitro culture of human-infecting Encephalitozoon spp. for genome sequencing with minimal host contaminant.PloS one · 2026Article
- Influence of host cell line and microsporidian species in the in vitro infection efficiency of Encephalitozoon spp.Parasite (Paris, France) · 2026Article
- Draft assemblies for three geographically distinct isolates of the human-infecting microsporidiumMicrobiology resource announcements · 2025Article
- Bioinformatics analysis of the Microsporidia sp. MB genome: a malaria transmission-blocking symbiont of the Anopheles arabiensis mosquito.BMC genomics · 2024Article
- Polyploidy is widespread in Microsporidia.Microbiology spectrum · 2024Article
- Near chromosome-level genome assembly of the microsporidium Hamiltosporidium tvaerminnensis.G3 (Bethesda, Md.) · 2023Article
- Telomere-to-Telomere genome assemblies of human-infecting Encephalitozoon species.BMC genomics · 2023Article
- First report ofParasitology · 2022Article
- Comparative Genomics of Microsporidia.Experientia supplementum (2012) · 2022Article
- Genome and Evolutionary Analysis ofFrontiers in microbiology · 2021Article
- Evolution of microsporidia: An extremely successful group of eukaryotic intracellular parasites.PLoS pathogens · 2020Article
- Microsporidia with Vertical Transmission Were Likely Shaped by Nonadaptive Processes.Genome biology and evolution · 2020Article
- Genetic and Genome Analyses Reveal Genetically Distinct Populations of the Bee Pathogen Nosema ceranae from Thailand.Microbial ecology · 2019Article
- Multilocus Sequence Typing and Population Genetic Analysis ofFrontiers in genetics · 2019Article
- Parasite infection and host personality:Behavioral ecology and sociobiology · 2018Article
- Dynamics of parasitophorous vacuoles formed by the microsporidian pathogen Encephalitozoon cuniculi.Fungal genetics and biology : FG & B · 2017Article
- Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species.PLoS neglected tropical diseases · 2017Article
- Fungal Genomes and Insights into the Evolution of the Kingdom.Microbiology spectrum · 2017Article
- Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Microsporidia from the Encephalitozoonidae are obligate intracellular parasites with highly conserved and compacted nuclear genomes: they have few introns, short intergenic regions, and almost identical gene complements and chromosome arrangements. Comparative genomics of Encephalitozoon and microsporidia in general have focused largely on the genomic diversity between different species, and we know very little about the levels of genetic diversity within species. Polymorphism studies with Encephalitozoon are so far restricted to a small number of genes, and a few genetically distinct strains have been identified; most notably, three genotypes (ECI, ECII, and ECIII) of the model species E. cuniculi have been identified based on variable repeats in the rRNA internal transcribed spacer (ITS). To determine if E. cuniculi genotypes are genetically distinct lineages across the entire genome and at the same time to examine the question of intraspecies genetic diversity in microsporidia in general, we sequenced de novo genomes from each of the three genotypes and analyzed patterns of single nucleotide polymorphisms (SNPs) and insertions/deletions across the genomes. Although the strains have almost identical gene contents, they harbor large numbers of SNPs, including numerous nonsynonymous changes, indicating massive intraspecies variation within the Encephalitozoonidae. Based on this diversity, we conclude that the recognized genotypes are genetically distinct and propose new molecular markers for microsporidian genotyping.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.