Evidence map›Paper›PMID 23291605›Full record

Trial reportAmerican journal of physical medicine & rehabilitation2013

Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): results of a single-blind, pilot-level, randomized controlled trial.

David Rabago, Ken S Lee, Michael Ryan, Amrish O Chourasia, Mary E Sesto, Aleksandra Zgierska, Rick Kijowski, Jessica Grettie, John Wilson, Daniel Miller

Open access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physical medicine & rehabilitation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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  10. [Infiltration therapies for lateral epicondylopathy].Orthopadie (Heidelberg, Germany) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

David RabagoDepartment of Family Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53715, USA.
Ken S Lee
Michael Ryan
Amrish O Chourasia
Mary E Sesto
Aleksandra Zgierska
Rick Kijowski
Jessica Grettie
John Wilson
Daniel Miller
Madison Group (United States) · US

Funding

INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
Mindfulness Meditation for Alcohol Relapse PreventionK23AA017508 · NIAAA · UNIVERSITY OF WISCONSIN-MADISON · PI ZGIERSKA, ALEKSANDRA EWA · 2009 to 2013
$918k
The Efficacy of Prolotherapy in Osteoarthritic Knee PainK23AT001879 · NCCIH · UNIVERSITY OF WISCONSIN-MADISON · PI RABAGO, DAVID P · 2004 to 2008
$601k
NCCIH NIH HHS K23 AT001879NCRR NIH HHS UL1 RR025011NIAAA NIH HHS K23 AA017508
6 · The paper itself

Abstract

objectiveChronic lateral epicondylosis is common, debilitating, and often refractory. Prolotherapy (PrT) is an injection therapy for tendinopathy. The efficacy of two PrT solutions for chronic lateral epicondylosis was evaluated.

designThis study is a three-arm randomized controlled trial. Twenty-six adults (32 elbows) with chronic lateral epicondylosis for 3 mos or longer were randomized to ultrasound-guided PrT with dextrose solution, ultrasound-guided PrT with dextrose-morrhuate sodium solution, or watchful waiting ("wait and see"). The primary outcome was the Patient-Rated Tennis Elbow Evaluation (100 points) at 4, 8, and 16 wks (all groups) and at 32 wks (PrT groups). The secondary outcomes included pain-free grip strength and magnetic resonance imaging severity score.

resultsThe participants receiving PrT with dextrose and PrT with dextrose-morrhuate reported improved Patient-Rated Tennis Elbow Evaluation composite and subscale scores at 4, 8, and/or 16 wks compared with those in the wait-and-see group (P < 0.05). At 16 wks, compared with baseline, the PrT with dextrose and PrT with dextrose-morrhuate groups reported improved composite Patient-Rated Tennis Elbow Evaluation scores by a mean (SE) of 18.7 (9.6; 41.1%) and 17.5 (11.6; 53.5%) points, respectively. The grip strength of the participants receiving PrT with dextrose exceeded that of the PrT with dextrose-morrhuate and the wait and see at 8 and 16 wks (P < 0.05). There were no differences in magnetic resonance imaging scores. Satisfaction was high; there were no adverse events.

conclusionsPrT resulted in safe, significant improvement of elbow pain and function compared with baseline status and follow-up data and the wait-and-see control group. This pilot study suggests the need for a definitive trial.

Indexed as

Quality of LifeAdultChronic DiseaseDrug Therapy, CombinationFemaleFollow-Up StudiesGlucose Solution, HypertonicHumansInjections, Intra-ArticularMaleMiddle AgedPain MeasurementPilot ProjectsRange of Motion, ArticularReference ValuesRisk AssessmentGlucose Solution, HypertonicSodium Morrhuate

Identifiers

PMID23291605
PMCPMC3700532
OpenAlexW1979384190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.