ArticleBone2013
IGFBP-2 is a negative predictor of cold-induced brown fat and bone mineral density in young non-obese women.
Article in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Bone density and genomic analysis unfold cold adaptation mechanisms of ancient inhabitants of Tierra del Fuego.Scientific reports · 2021Article
- Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential.International journal of molecular sciences · 2021Review
- Sexual Dimorphism and the Origins of Human Spinal Health.Endocrine reviews · 2018Review
- Brown and beige adipose tissues: phenotype and metabolic potential in mice and men.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Effects of collagen peptides intake on skin ageing and platelet release in chronologically aged mice revealed by cytokine array analysis.Journal of cellular and molecular medicine · 2018Article
- Long non-coding RNAs could act as vectors for paternal heredity of high fat diet-induced obesity.Oncotarget · 2017Article
- 'Browning' the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk.International journal of cardiology · 2017Review
- Article
- Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss.Endocrinology · 2015Article
- Muscle-bone and fat-bone interactions in regulating bone mass: do PTH and PTHrP play any role?Endocrine · 2014Review
- Fat and bone interactions.Current osteoporosis reports · 2014Review
- Muscle-bone interactions: basic and clinical aspects.Endocrine · 2014Review
- Article
- Anorexia nervosa, obesity and bone metabolism.Pediatric endocrinology reviews : PER · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Recent studies have shown a positive correlation between brown adipose tissue (BAT) and bone mineral density (BMD). However, mechanisms underlying this relationship are unknown. Insulin-like growth factor 1 (IGF-1) is an important regulator of stem cell differentiation promoting bone formation. IGF binding protein 2 (IGFBP-2) binds IGF-1 in the circulation and has been reported to inhibit bone formation in humans. IGF-1 is also a crucial regulator of brown adipocyte differentiation. We hypothesized that IGFBP-2 is a negative and IGF-1 a positive regulator of BAT-mediated osteoblastogenesis. We therefore investigated a cohort of 15 women (mean age 27.7±5.7years): 5 with anorexia nervosa (AN) in whom IGF-1 levels were low due to starvation, 5 recovered AN (AN-R), and 5 women of normal weight. All subjects underwent assessment of cold-activated BAT by PET/CT, BMD of the spine, hip, femoral neck, and total body by DXA, thigh muscle area by MRI, IGF-1 and IGFBP-2. There was a positive correlation between BAT and BMD and an inverse association between IGFBP-2 and both BAT and BMD. There was no association between IGF-1 and BAT. We show for the first time that IGFBP-2 is a negative predictor of cold-induced BAT and BMD in young non-obese women, suggesting that IGFBP-2 may serve as a regulator of BAT-mediated osteoblastogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.