ArticleToxicological sciences : an official journal of the Society of Toxicology2013
Aryl hydrocarbon receptor activation attenuates Per1 gene induction and influences circadian clock resetting.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Circadian synchronization between diet and gut microbiota in modulating host's health.Gut microbes · 2026Review
- Systemic rhythmicity of host and bacterial bile acid amidates in the mouse.Cell systems · 2026Article
- Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders?Journal of clinical medicine · 2024Review
- Aryl hydrocarbon receptor affects circadian-regulated lipolysis through an E-Box-dependent mechanism.Molecular and cellular endocrinology · 2023Article
- Control of Arterial Hypertension by the AhR Blocker CH-223191: A Chronopharmacological Study in Chronic Intermittent Hypoxia Conditions.Advances in experimental medicine and biology · 2023Article
- TCDD exposure alters fecal IgA concentrations in male and female mice.BMC pharmacology & toxicology · 2022Article
- Aryl hydrocarbon receptor: Its roles in physiology.Biochemical pharmacology · 2021Review
- Pharmacological Actions of Carbamate Insecticides at Mammalian Melatonin Receptors.The Journal of pharmacology and experimental therapeutics · 2021Article
- Cross-species physiological interactions of endocrine disrupting chemicals with the circadian clock.General and comparative endocrinology · 2021Review
- Metabolic rivalry: circadian homeostasis and tumorigenesis.Nature reviews. Cancer · 2020Review
- Mechanisms of circadian clock interactions with aryl hydrocarbon receptor signalling.The European journal of neuroscience · 2020Article
- Aryl hydrocarbon receptor-deficient mice are protected from high fat diet-induced changes in metabolic rhythms.Chronobiology international · 2017Article
- Regulation of Innate Lymphoid Cells by Aryl Hydrocarbon Receptor.Frontiers in immunology · 2017Review
- Biological Rhythms in the Skin.International journal of molecular sciences · 2016Review
- Migration-related phenotypic divergence is associated with epigenetic modifications in rainbow trout.Molecular ecology · 2016Article
- Role of Aryl Hydrocarbon Receptor in Circadian Clock Disruption and Metabolic Dysfunction.Environmental health insights · 2016Review
- Interplay between Dioxin-mediated signaling and circadian clock: a possible determinant in metabolic homeostasis.International journal of molecular sciences · 2014Review
- The circadian clock in cancer development and therapy.Progress in molecular biology and translational science · 2013Review
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Authors and funding
5 authors.
Funding
Abstract
Light-stimulated adjustment of the circadian clock is an important adaptive physiological response that allows maintenance of behavioral synchrony with solar time. Our previous studies indicate that the aryl hydrocarbon receptor (AhR) agonist 2,3,7,8- tetrachlorodibenzo-p-dioxin attenuates light-induced phase resetting in early night. However, the mechanism of inhibition remains unclear. In this study, we showed that another potent AhR agonist-β-naphthoflavone (BNF)-significantly decreased light-induced phase shifts in wild-type (WT) mice, whereas AhR knockout mice had an enhanced response to light that was unaffected by BNF. Mechanistically, BNF blocked light induction of the Per1 transcript in suprachiasmatic nucleus and liver in WT mice, and BNF blocked forskolin (FSK)-induced Per1 transcripts in Hepa-1c1c7 (c7) cells. An E-box decoy did not affect BNF inhibition of FSK-induced Per1 transcripts in c7 cells. cAMP-response element (CRE)-dependent induction of Per1 promoter activity in response to FSK in combination with phorbol 12-tetradecanoate 13-acetate was suppressed in cells that expressed high levels of AhR (c7) compared with cells lacking functional AhR activity (c12). In addition, the inhibitory effect of BNF on FSK-induced Per1 was dependent on phosphorylation of JNK. Together, these results suggest that AhR activation inhibits light-induced phase resetting through the activation of JNK, negative regulation of CREs in the Per1 promoter, and suppression of Per1.
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