ArticleJournal of ethnopharmacology2013
Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia.
Article in Journal of ethnopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 92 citations in OpenAlex.
- [Isolation, purification and immunomodulatory activity of polysaccharide fromNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- The GenusMolecules (Basel, Switzerland) · 2026Review
- Barrier Tissue-Resident Macrophages: Natural Compounds as Modulators in Immune Function and Disease.Current topics in medicinal chemistry · 2026Review
- Synthetic short peptide mimicking IsdB and IsdH conserved motifs selectively bind and enable detection ofFrontiers in immunology · 2026Article
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- The role of total polysaccharides fromFrontiers in pharmacology · 2025Article
- The Potential of Plant Polysaccharides and Chemotherapeutic Drug Combinations in the Suppression of Breast Cancer.International journal of molecular sciences · 2024Review
- Unraveling the web of defense: the crucial role of polysaccharides in immunity.Frontiers in immunology · 2024Review
- Beyond cellulose: pharmaceutical potential for bioactive plant polysaccharides in treating disease and gut dysbiosis.Frontiers in microbiology · 2023Review
- Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro.Viruses · 2022Article
- Immune-Enhancing Effects of Crude Polysaccharides from Korean Ginseng Berries on Spleens of Mice with Cyclophosphamide-Induced Immunosuppression.Journal of microbiology and biotechnology · 2022Article
- Therapeutic Potential of Natural Plants Against Non-Alcoholic Fatty Liver Disease: Targeting the Interplay Between Gut Microbiota and Bile Acids.Frontiers in cellular and infection microbiology · 2022Review
- M1 Polarization but Anti-LPS-Induced Inflammation and Anti-MCF-7 Breast Cancer Cell Growth Effects of Five Selected Polysaccharides.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- The protective effects of polysaccharide extract from Xin-Ji-Er-Kang formula on Ang II-induced HUVECs injury, L-NAME-induced hypertension and cardiovascular remodeling in mice.BMC complementary and alternative medicine · 2019Article
- Advances in Research on Immunoregulation of Macrophages by Plant Polysaccharides.Frontiers in immunology · 2019Review
- Laminarin enhances the activity of natural killer cells in immunosuppressed mice.Central-European journal of immunology · 2019Article
- Isolation, Characterization and Antitumor Effect on DU145 Cells of a Main Polysaccharide in Pollen of Chinese Wolfberry.Molecules (Basel, Switzerland) · 2018Article
- Effects of polysaccharide fractions isolated fromThe Indian journal of medical research · 2017Article
- Dioscorea bulbifera polysaccharide and cyclophosphamide combination enhances anti-cervical cancer effect and attenuates immunosuppression and oxidative stress in mice.Scientific reports · 2016Article
- Antioxidant and immunomodulatory properties of polysaccharides from Allanblackia floribunda Oliv stem bark and Chromolaena odorata (L.) King and H.E. Robins leaves.BMC research notes · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
ethnopharmacological relevanceExtracts of leaves from different species of the genus Alchornea have been used for centuries to treat a variety of medicinal problems in tropical Africa. However, little is known about the high-molecular weight active components conferring therapeutic properties to these extracts.
objectiveThe aim of this study was to evaluate the immunomodulatory activity of polysaccharides isolated from the leaves of Alchornea cordifolia. MATERIALS AND
methodsWater-soluble polysaccharides from leaves of Alchornea cordifolia were extracted and fractionated by DEAE-cellulose, Diaion HP-20, and size-exclusion chromatography. Molecular weight, sugar analysis, and other physical and chemical characterization of the fractions were performed. Immunomodulatory activity of the polysaccharide fractions was evaluated by determining their ability to induce monocyte/macrophage nitric oxide (NO) and cytokine production. Activation of mitogen activated protein kinases (MAPK) was also assessed using a phospho-MAPK array. Activation of nuclear factor κB (NF-κB) was measured using an alkaline phosphatase reporter gene assay in THP1-Blue monocytic cells.
resultsSix polysaccharide fractions from Alchornea cordifolia were isolated. Fractions containing type II arabinogalactan had potent immunomodulatory activity. Particularly, the parent fraction AP-AU and its high-molecular weight sub-fraction AP-AU1 (average M(r) was estimated to be 39.5kDa) induced production of NO and cytokines [interleukin (IL)-1β, -6, -10, tumor necrosis factor (TNF)-α, and granulocyte-macrophage-colony stimulating factor (GM-CSF)] in human peripheral blood mononuclear cells and human and murine monocyte/macrophages cell lines in vitro. Furthermore, treatment with AP-AU1 induced phosphorylation of Akt2, p38δ/p38γ, p70S6K1, RSK2, and mTOR, as well as stimulation of NF-κB transcriptional activity.
conclusionOur results provide a molecular basis to explain a portion of the beneficial therapeutic properties of water extracts from Alchornea cordifolia leaves in traditional folk medicine of Africa.
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