ReviewNeuroscience2013
Testosterone modulation of angiogenesis and neurogenesis in the adult songbird brain.
Review in Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The Impact of Testosterone Supplementation on Surgical Complications in Gender-Affirming Mastectomy: A Meta-Analysis.Aesthetic plastic surgery · 2026Pooled it
- Cholinergic signaling differentially regulates a vocal motor pallial nucleus to stabilize adult birdsong.Communications biology · 2026Article
- Sex Steroids and Brain-Derived Neurotrophic Factor Interactions in the Nervous System: A Comprehensive Review of Scientific Data.International journal of molecular sciences · 2025Review
- The quantitative anatomy of the hippocampal formation in homing pigeons and other pigeon breeds: implications for spatial cognition.Brain structure & function · 2024Article
- Hypophysial angiogenesis decodes annual time and underlies physiological adaptation to seasonal changes in the environment.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2022Article
- Understanding patterns of heterogeneity in executive functioning during adolescence: Evidence from population-level data.Developmental science · 2022Article
- Testosterone Replacement Therapy in the Treatment of Depression.Health psychology research · 2022Article
- New Perspectives on Avian Models for Studies of Basic Aging Processes.Biomedicines · 2021Review
- Developmental polychlorinated biphenyl exposure influences adult zebra finch reproductive behaviour.PloS one · 2020Article
- Sex steroid hormone modulation of neural stem cells: a critical review.Biology of sex differences · 2019Review
- Tissue Clearing and Light Sheet Microscopy: Imaging the Unsectioned Adult Zebra Finch Brain at Cellular Resolution.Frontiers in neuroanatomy · 2019Article
- Androgen induced cellular proliferation, neurogenesis, and generation of GnRH3 neurons in the brain of mature female Mozambique tilapia.Scientific reports · 2018Article
- Androgen and estrogen sensitivity of bird song: a comparative view on gene regulatory levels.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- 11β-HSD Types 1 and 2 in the Songbird Brain.Frontiers in endocrinology · 2018Article
- Multimodality management and outcomes of brain arterio-venous malformations (AVMs) in children: personal experience and review of the literature, with specific emphasis on age at first AVM bleed.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Mechanisms regulating angiogenesis underlie seasonal control of pituitary function.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Gene Expression Profiling in the Injured Spinal Cord ofFrontiers in molecular neuroscience · 2017Article
- Article
- Sex and age differences in brain-derived neurotrophic factor and vimentin in the zebra finch song system: Relationships to newly generated cells.The Journal of comparative neurology · 2016Article
- Determinants and significance of corticosterone regulation in the songbird brain.General and comparative endocrinology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Throughout life, new neurons arise from the ventricular zone of the adult songbird brain and are recruited to the song control nucleus higher vocal center (HVC), from which they extend projections to its target, nucleus robustus of the arcopallium (RA). This process of ongoing parenchymal neuronal addition and circuit integration is both triggered and modulated by seasonal surges in systemic testosterone. Brain aromatase converts circulating testosterone to estradiol, so that HVC is concurrently exposed to both androgenic and estrogenic stimulation. These two signals cooperate to trigger HVC endothelial cell division and angiogenesis, by inducing the regionally-restricted expression of vascular endothelial growth factor (VEGF), its matrix-releasing protease MMP9, and its endothelial receptor VEGFR2. The expanded HVC microvascular network then secretes the neurotrophic factor BDNF, which in turn supports the recruitment of newly generated neurons. This process is striking for its spatial restriction and hence functional specificity. While androgen receptors are broadly expressed by the nuclei of the vocal control system, estrogen receptor (ERα) expression is largely restricted to HVC and its adjacent mediocaudal neopallium. The geographic overlap of these receptor phenotypes in HVC provides the basis for a regionally-defined set of paracrine interactions between the vascular bed and neuronal progenitor pool that both characterize and distinguish this nucleus. These interactions culminate in the focal attraction of new neurons to the adult HVC, the integration of those neurons into the extant vocal control circuits, and ultimately the acquisition and elaboration of song.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.