Evidence map›Paper›PMID 23291191›Full record

ReviewBiochimica et biophysica acta2013

Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.

Andrew P Wojtovich, C Owen Smith, Cole M Haynes, Keith W Nehrke, Paul S Brookes

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Review
  2. Vascular changes and their implications in lipedema.Frontiers in cell and developmental biology · 2026
    Review
  3. Intracerebral Transplantation of Enteric Glia.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Active control of mitochondrial network morphology by metabolism-driven redox state.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Complex II Biology in Aging, Health, and Disease.Antioxidants (Basel, Switzerland) · 2023
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Bioenergetic Metabolism In Osteoblast Differentiation.Current osteoporosis reports · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew P WojtovichDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
C Owen Smith
Cole M Haynes
Keith W Nehrke
Paul S Brookes

Funding

SIRT1, Nitro-Lipids and CardioprotectionR01HL071158 · NHLBI · UNIVERSITY OF ROCHESTER · PI BROOKES, PAUL S · 2003 to 2025
$7.7M
Mitochondrial K+ Channels and CardioprotectionR01GM087483 · NIGMS · UNIVERSITY OF ROCHESTER · PI BROOKES, PAUL S, NEHRKE, KEITH · 2010 to 2017
$2.3M
NHLBI NIH HHS HL071158NHLBI NIH HHS R01 HL071158NIGMS NIH HHS GM087483NIGMS NIH HHS R01 GM087483
6 · The paper itself

Abstract

In recent years, it has become apparent that there exist several roles for respiratory complex II beyond metabolism. These include: (i) succinate signaling, (ii) reactive oxygen species (ROS) generation, (iii) ischemic preconditioning, (iv) various disease states and aging, and (v) a role in the function of the mitochondrial ATP-sensitive K(+) (mKATP) channel. This review will address the involvement of complex II in each of these areas, with a focus on how complex II regulates or may be involved in the assembly of the mKATP. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.

Indexed as

MutationAdenosine TriphosphateAgingElectron Transport Complex IIHumansModels, BiologicalNeoplasmsPhysiological PhenomenaPotassium ChannelsAdenosine TriphosphateElectron Transport Complex IImitochondrial K(ATP) channelPotassium Channelsrespiratory complex II

Identifiers

PMID23291191
PMCPMC3880126

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.