ReviewSeminars in immunology2012
Matched and mismatched metabolic fuels in lymphocyte function.
Review in Seminars in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Metabolism and Immune Suppressive Response in Liver Cancer.Biomedicines · 2025Review
- Dual phosphorylation of glycogen synthase kinase 3β differentially integrates metabolic programs to determine T cell immunity across vertebrates.Cellular and molecular life sciences : CMLS · 2025Article
- Stress-Induced Immunosuppression Inhibits Regional Immune Responses in Chicken Adipose Tissue Partially through Suppressing T Cells by Up-Regulating Steroid Metabolism.Animals : an open access journal from MDPI · 2024Article
- Fatty acids are crucial to fuel NK cells upon acute retrovirus infection.Frontiers in immunology · 2023Article
- Lipid metabolism in tumor immunology and immunotherapy.Frontiers in oncology · 2023Review
- Influence of Yeast Products on Modulating Metabolism and Immunity in Cattle and Swine.Animals : an open access journal from MDPI · 2021Review
- Reduced Energy Metabolism Impairs T Cell-Dependent B Cell Responses in Patients With Advanced HBV-Related Cirrhosis.Frontiers in immunology · 2021Article
- mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality.JCI insight · 2019Article
- mTOR and Aging: An Old Fashioned Dress.International journal of molecular sciences · 2019Review
- From zero to sixty and back to zero again: the metabolic life of B cells.Current opinion in immunology · 2019Review
- Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Mitochondrial fidelity and metabolic agility control immune cell fate and function.The Journal of clinical investigation · 2018Review
- Second signals rescue B cells from activation-induced mitochondrial dysfunction and death.Nature immunology · 2018Article
- mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation.Cell reports · 2018Article
- CD38-NADCell metabolism · 2018Article
- A Novel Glycoproteomics Workflow Reveals Dynamic O-GlcNAcylation of COPγ1 as a Candidate Regulator of Protein Trafficking.Frontiers in endocrinology · 2018Article
- Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity.Biomedical reports · 2017Article
- Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.The Journal of clinical investigation · 2016Article
- Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus.Immunity · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Immunological function requires metabolic support to suit the needs of lymphocytes at a variety of distinct differentiation and activation states. It is now evident that the signaling pathways that drive lymphocyte survival and activity can directly control cellular metabolism. This linkage provides a mechanism by which activation and specific signaling pathways provide a supply of appropriate and required nutrients to support cell functions in a pro-active supply rather than consumption-based metabolic model. In this way, the metabolism and fuel choices of lymphocytes are guided to specifically match the anticipated needs. If the fuel choice or metabolic pathways of lymphocytes are dysregulated, however, metabolic checkpoints can become activated to disrupt immunological function. These changes are now shown in several immunological diseases and may open new opportunities to selectively enhance or suppress specific immune functions through targeting of glucose, lipid, or amino acid metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.