ArticleStructure (London, England : 1993)2013
Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities.
Article in Structure (London, England : 1993), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems.Chemical reviews · 2022Review
- Redox and Hormonal Changes in the Transcriptome of Grape (Plants (Basel, Switzerland) · 2022Article
- Inhibition of Type 2C Protein Phosphatases by ABA Receptors in Abscisic Acid-Mediated Plant Stress Responses.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A Steric "Ball-and-Chain" Mechanism for pH-Mediated Regulation of Gap Junction Channels.Cell reports · 2020Article
- Comprehensive survey of the VxGΦL motif of PP2Cs from Oryza sativa reveals the critical role of the fourth position in regulation of ABA responsiveness.Plant molecular biology · 2019Article
- Optimized Workflow for Selecting Peptides for HDX-MS Data Analyses.Journal of the American Society for Mass Spectrometry · 2018Article
- Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.Cell · 2017Article
- Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.Biochemistry · 2017Article
- Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry.Current opinion in structural biology · 2016Review
- Synthetic RORγt Agonists Enhance Protective Immunity.ACS chemical biology · 2016Article
- Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling.PLoS genetics · 2016Article
- Article
- Applications of hydrogen/deuterium exchange MS from 2012 to 2014.Analytical chemistry · 2015Review
- High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5.Nucleic acids research · 2015Article
- Nitric oxide-induced conformational changes in soluble guanylate cyclase.Structure (London, England : 1993) · 2014Article
- Interactions between soybean ABA receptors and type 2C protein phosphatases.Plant molecular biology · 2013Article
- Regulation of the structurally dynamic N-terminal domain of progesterone receptor by protein-induced folding.The Journal of biological chemistry · 2013Article
- Time window expansion for HDX analysis of an intrinsically disordered protein.Journal of the American Society for Mass Spectrometry · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Plants regulate growth and respond to environmental stress through abscisic acid (ABA) regulated pathways, and as such these pathways are of primary interest for biological and agricultural research. The ABA response is first perceived by the PYR/PYL/RCAR class of START protein receptors. These ABA activated receptors disrupt phosphatase inhibition of Snf1-related kinases (SnRKs), enabling kinase signaling. Here, insights into the structural mechanism of proteins in the ABA signaling pathway (the ABA receptor PYL2, HAB1 phosphatase, and two kinases, SnRK2.3 and 2.6) are discerned through hydrogen/deuterium exchange (HDX) mass spectrometry. HDX on the phosphatase in the presence of binding partners provides evidence for receptor-specific conformations involving the Trp385 "lock" that is necessary for signaling. Furthermore, kinase activity is linked to a more stable "closed" conformation. These solution-based studies complement the static crystal structures and provide a more detailed understanding of the ABA signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.