ArticleSchizophrenia research2013
Abnormalities of middle longitudinal fascicle and disorganization in patients with schizophrenia.
Article in Schizophrenia research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.The American journal of psychiatry · 2025Pooled it
- Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.Translational psychiatry · 2021Pooled it
- Functional connectivity signatures of NMDAR dysfunction in schizophrenia-integrating findings from imaging genetics and pharmaco-fMRI.Translational psychiatry · 2023Trial
- Trial
- An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- White matter tract crossing and bottleneck regions in the fetal brain.bioRxiv : the preprint server for biology · 2024Article
- A detailed spatio-temporal atlas of the white matter tracts for the fetal brain.bioRxiv : the preprint server for biology · 2024Article
- The Neurobiology of Formal Thought Disorder.Current topics in medicinal chemistry · 2024Review
- Neural Correlates of Formal Thought Disorder Dimensions in Psychosis.Schizophrenia bulletin · 2023Article
- Language abnormalities in schizophrenia: binding core symptoms through contemporary empirical evidence.Schizophrenia (Heidelberg, Germany) · 2022Review
- Abnormal semantic processing of threat words associated with excitement and hostility symptoms in schizophrenia.Schizophrenia research · 2021Article
- Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study.NPJ schizophrenia · 2021Article
- A Human Induced Pluripotent Stem Cell-Derived Tissue Model of a Cerebral Tract Connecting Two Cortical Regions.iScience · 2019Article
- White matter correlates of the disorganized speech dimension in schizophrenia.European archives of psychiatry and clinical neuroscience · 2018Article
- Altered white matter connectivity in patients with schizophrenia: An investigation using public neuroimaging data from SchizConnect.PloS one · 2018Article
- Mapping temporo-parietal and temporo-occipital cortico-cortical connections of the human middle longitudinal fascicle in subject-specific, probabilistic, and stereotaxic Talairach spaces.Brain imaging and behavior · 2017Article
- The white matter query language: a novel approach for describing human white matter anatomy.Brain structure & function · 2016Article
- Selective Functional Disconnection of the Dorsal Subregion of the Temporal Pole in Schizophrenia.Scientific reports · 2015Article
- A network view on psychiatric disorders: network clusters of symptoms as elementary syndromes of psychopathology.PloS one · 2014Article
- Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography.Brain imaging and behavior · 2013Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionThe middle longitudinal fascicle (MdLF) is a long association fiber connecting the superior temporal gyrus (STG) and temporal pole with the angular gyrus through the white matter of the STG, structures which are known to play a crucial role in the pathology of schizophrenia. Functions of MdLF are thought to be related to language and thought processing in the left hemisphere, and with attention in the right hemisphere. While deficits of these functions are core clinical features of schizophrenia, no study has investigated the structural abnormalities of MdLF in schizophrenia.
method3T diffusion tensor data was acquired from twenty-six patients with schizophrenia and twenty-five healthy control subjects. Streamline tractography technique was used to extract MdLF. Fractional anisotropy (FA) was compared between the two groups. In addition, relationships were investigated between FA in the left MdLF and the Disorganized Thoughts Factor derived from the Positive and Negative Symptom Scale five factor model, and between FA in the right MdLF and the Poor Attention.
resultRelative to control subjects, the patients with chronic schizophrenia showed significant mean FA reductions in the bilateral MdLF. The FA of the left MdLF demonstrated a significant negative association with the Disorganized Thoughts Factor, and the FA of the right MdLF showed a significant negative relationship with the Poor Attention.
conclusionsThis study provides new evidence for structural deficits in the bilateral MdLF in patients with chronic schizophrenia. It further demonstrates the contribution of these abnormalities to the core clinical features - especially to disorganization and attention deficit.
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