ArticleJournal of psychiatric research2013
Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder.
Article in Journal of psychiatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Neurobiological outcomes of cognitive behavioral therapy for obsessive-compulsive disorder: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Defining functional brain networks underlying obsessive-compulsive disorder (OCD) using treatment-induced neuroimaging changes: a systematic review of the literature.Journal of neurology, neurosurgery, and psychiatry · 2021Pooled it
- Effects of short-term cognitive-coping therapy on resting-state brain function in obsessive-compulsive disorder.Brain and behavior · 2021Trial
- Glutamate in Pediatric Obsessive-Compulsive Disorder and Response to Cognitive-Behavioral Therapy: Randomized Clinical Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial.BMC psychiatry · 2015Trial
- Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change.Neural plasticity · 2024Review
- Psychotherapies and digital interventions for OCD in adults: What do we know, what do we need still to explore?Comprehensive psychiatry · 2023Review
- Effects of Psychotherapy on Glutamatergic Neurotransmission.Neuropsychobiology · 2023Article
- Decreased left amygdala functional connectivity by cognitive-coping therapy in obsessive-compulsive disorder.Molecular psychiatry · 2021Article
- Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) Imaging in Obsessive-Compulsive Disorder.Current topics in behavioral neurosciences · 2021Article
- Is glutamate associated with fear extinction and cognitive behavior therapy outcome in OCD? A pilot study.European archives of psychiatry and clinical neuroscience · 2020Article
- Multi-level assessment of obsessive-compulsive disorder (OCD) reveals relations between neural and neurochemical levels.BMC psychiatry · 2020Article
- Effects of 12-Week Methylphenidate Treatment on Neurometabolism in Adult Patients with ADHD: The First Double-Blind Placebo-Controlled MR Spectroscopy Study.Journal of clinical medicine · 2020Article
- Caudate volume differences among treatment responders, non-responders and controls in children with obsessive-compulsive disorder.European child & adolescent psychiatry · 2019Article
- Differential neuroimaging indices in prefrontal white matter in prenatal alcohol-associated ADHD versus idiopathic ADHD.Birth defects research · 2019Article
- A new conception and subsequent taxonomy of clinical psychological problems.BMC psychology · 2019Article
- Neuroimaging findings in obsessive-compulsive disorder: A narrative review to elucidate neurobiological underpinnings.Indian journal of psychiatry · 2019Review
- Neurobiological Mechanisms of Metacognitive Therapy - An Experimental Paradigm.Frontiers in psychology · 2019Article
- Augmenting Buried in Treasures with in-home uncluttering practice: Pilot study in hoarding disorder.Journal of psychiatric research · 2018Article
- Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder.Translational psychiatry · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
The neurophysiological bases of cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder (OCD) are incompletely understood. Previous studies, though sparse, implicate metabolic changes in pregenual anterior cingulate cortex (pACC) and anterior middle cingulate cortex (aMCC) as neural correlates of response to CBT. The goal of this pilot study was to determine the relationship between levels of the neurochemically interlinked metabolites glutamate + glutamine (Glx) and N-acetyl-aspartate + N-acetyl-aspartyl-glutamate (tNAA) in pACC and aMCC to pretreatment OCD diagnostic status and OCD response to CBT. Proton magnetic resonance spectroscopic imaging ((1)H MRSI) was acquired from pACC and aMCC in 10 OCD patients at baseline, 8 of whom had a repeat scan after 4 weeks of intensive CBT. pACC was also scanned (baseline only) in 8 age-matched healthy controls. OCD symptoms improved markedly in 8/8 patients after CBT. In right pACC, tNAA was significantly lower in OCD patients than controls at baseline and then increased significantly after CBT. Baseline tNAA also correlated with post-CBT change in OCD symptom severity. In left aMCC, Glx decreased significantly after intensive CBT. These findings add to evidence implicating the pACC and aMCC as loci of the metabolic effects of CBT in OCD, particularly effects on glutamatergic and N-acetyl compounds. Moreover, these metabolic responses occurred after just 4 weeks of intensive CBT, compared to 3 months for standard weekly CBT. Baseline levels of tNAA in the pACC may be associated with response to CBT for OCD. Lateralization of metabolite effects of CBT, previously observed in subcortical nuclei and white matter, may also occur in cingulate cortex. Tentative mechanisms for these effects are discussed. Comorbid depressive symptoms in OCD patients may have contributed to metabolite effects, although baseline and post-CBT change in depression ratings varied with choline-compounds and myo-inositol rather than Glx or tNAA.
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Registered trials
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