ArticleCurrent biology : CB2013
Number of nuclear divisions in the Drosophila blastoderm controlled by onset of zygotic transcription.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Review
- Continuous transcriptome analysis reveals novel patterns of early gene expression inCell genomics · 2023Article
- Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization.Seminars in cell & developmental biology · 2023Review
- Dynamics ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Maternal body condition and season influence RNA deposition in the oocytes of alfalfa leafcutting bees (Frontiers in genetics · 2022Article
- Temporal Gradients Controlling Embryonic Cell Cycle.Biology · 2021Review
- The nuclear to cytoplasmic ratio directly regulates zygotic transcription inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Control of Cell Growth and Proliferation by the Tribbles Pseudokinase: Lessons from Drosophila.Cancers · 2021Review
- Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos.PLoS genetics · 2020Article
- Multiple Functions of the Essential GeneG3 (Bethesda, Md.) · 2019Article
- The role of dNTP metabolites in control of the embryonic cell cycle.Cell cycle (Georgetown, Tex.) · 2019Review
- Histone concentration regulates the cell cycle and transcription in early development.Development (Cambridge, England) · 2019Article
- Mechanisms regulating zygotic genome activation.Nature reviews. Genetics · 2019Review
- Regulatory principles governing the maternal-to-zygotic transition: insights from Drosophila melanogaster.Open biology · 2018Review
- Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development.Journal of developmental biology · 2018Review
- Article
- Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial Cell Cycles inG3 (Bethesda, Md.) · 2017Article
- Ploidy has little effect on timing early embryonic events in the haplo-diploid wasp Nasonia.Genesis (New York, N.Y. : 2000) · 2017Article
- Review
- Impact of gut microbiota on the fly's germ line.Nature communications · 2016Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The cell number of the early Drosophila embryo is determined by exactly 13 rounds of synchronous nuclear divisions, allowing cellularization and formation of the embryonic epithelium. The pause in G2 in cycle 14 is controlled by multiple pathways, such as activation of DNA repair checkpoint, progression through S phase, and inhibitory phosphorylation of Cdk1, involving the genes grapes, mei41, and wee1. In addition, degradation of maternal RNAs and zygotic gene expression are involved. The zinc finger Vielfältig (Vfl) controls expression of many early zygotic genes, including the mitotic inhibitor frühstart. The functional relationship of these pathways and the mechanism for triggering the cell-cycle pause have remained unclear. Here, we show that a novel single-nucleotide mutation in the 3' UTR of the RNPII215 gene leads to a reduced number of nuclear divisions that is accompanied by premature transcription of early zygotic genes and cellularization. The reduced number of nuclear divisions in mutant embryos depends on the transcription factor Vfl and on zygotic gene expression, but not on grapes, the mitotic inhibitor Frühstart, and the nucleocytoplasmic ratio. We propose that activation of zygotic gene expression is the trigger that determines the timely and concerted cell-cycle pause and cellularization.
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