ArticleCurrent biology : CB2013
Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 60 citations in OpenAlex.
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- The nuclear to cytoplasmic ratio directly regulates zygotic transcription inProceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio.PLoS biology · 2020Article
- Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos.PLoS genetics · 2020Article
- Multiple Functions of the Essential GeneG3 (Bethesda, Md.) · 2019Article
- The role of dNTP metabolites in control of the embryonic cell cycle.Cell cycle (Georgetown, Tex.) · 2019Review
- Histone concentration regulates the cell cycle and transcription in early development.Development (Cambridge, England) · 2019Article
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6 authors at 1 institution in 1 country.
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Abstract
In most metazoans, early embryonic development is characterized by rapid mitotic divisions that are controlled by maternal mRNAs and proteins that accumulate during oogenesis. These rapid divisions pause at the midblastula transition (MBT), coinciding with a dramatic increase in gene transcription and the degradation of a subset of maternal mRNAs. In Drosophila, the cell-cycle pause is controlled by inhibitory phosphorylation of Cdk1, which in turn is driven by downregulation of the activating Cdc25 phosphatases. Here, we show that the two Drosophila Cdc25 homologs, String and Twine, differ in their dynamics and that, contrary to current models, their downregulations are not controlled by mRNA degradation but through different posttranslational mechanisms. The degradation rate of String protein gradually increases during the late syncytial cycles in a manner dependent on the nuclear-to-cytoplasmic ratio and on the DNA replication checkpoints. Twine, on the other hand, is targeted for degradation at the onset of the MBT through a switch-like mechanism controlled, like String, by the nuclear-to-cytoplasmic ratio, but not requiring the DNA replication checkpoints. We demonstrate that posttranslational control of Twine degradation ensures that the proper number of mitoses precede the MBT.
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