ArticleHistochemistry1990
Origin of intrafusal muscle fibers in the rat.
Article in Histochemistry, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Co-expression of MyHC-15 with other known isoforms in rat muscle spindles.European journal of histochemistry : EJH · 2025Article
- Neuregulin 1 Drives Morphological and Phenotypical Changes in C2C12 Myotubes: TowardsFrontiers in cell and developmental biology · 2021Article
- Tissue engineering the mechanosensory circuit of the stretch reflex arc: sensory neuron innervation of intrafusal muscle fibers.Biomaterials · 2010Article
- Tissue engineering intrafusal fibers: dose- and time-dependent differentiation of nuclear bag fibers in a defined in vitro system using neuregulin 1-beta-1.Biomaterials · 2008Article
- Expression of Myosin heavy chain isoforms in rat soleus muscle spindles after 19 days of hypergravity.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2003Article
- Origin of intrafusal fibers from a subset of primary myotubes in the rat.Anatomy and embryology · 1995Article
- An immunocytochemical marker for early type I muscle fibers in the developing rat hindlimb.Anatomy and embryology · 1995Article
- Neomyogenesis in neonatally de-efferented and postnatally denervated rat muscle spindles.Acta neuropathologica · 1995Article
- Sequences of intrafusal fiber formation are muscle-dependent in rat hindlimbs.Anatomy and embryology · 1994Article
- Intrafusal motor innervation: a quantitative histological analysis of tenuissimus muscle spindles in the cat.Journal of anatomy · 1994Article
- Development of chicken intrafusal muscle fibers.Cell and tissue research · 1993Article
- Transient expression of a slow-tonic MHC isoform by extrafusal fibers in the developing rat.Anatomy and embryology · 1993Article
- Transient expression of a ventricular myosin heavy chain isoform in developing chicken intrafusal muscle fibers.Histochemistry · 1993Article
- Differential effects of neonatal denervation on intrafusal muscle fibers in the rat.Anatomy and embryology · 1993Article
- Superfluousness of motor innervation for the formation of muscle spindles in neonatal rats.Anatomy and embryology · 1992Article
- Calbindin D-28k-immunoreactivity in rat muscle spindles during postnatal maturation and after denervation.The Histochemical journal · 1992Article
- Myosin isoform transitions during development of extra-ocular and masticatory muscles in the fetal rat.Anatomy and embryology · 1992Article
- Rat muscle spindle immunocytochemistry revisited.Histochemistry · 1991Article
- Aggregation of myonuclei and the spread of slow-tonic myosin immunoreactivity in developing muscle spindles.Histochemistry · 1991Article
- Slow-tonic MHC expression in paralyzed hindlimbs of fetal rats.Histochemistry · 1991Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The expression of several isoforms of myosin heavy chain (MHC) by intrafusal and extrafusal fibers of the rat soleus muscle at different stages of development was compared by immunocytochemistry. The first intrafusal myotube to form, the bag2 fiber, expressed a slow-twitch MHC isoform identical to that expressed by the primary extrafusal myotubes. The second intrafusal myotube to form, the bag1 fiber, expressed a fast-twitch MHC similar to that initially expressed by the secondary extrafusal myotubes. At subsequent stages of development, the equatorial and juxtaequatorial regions of bag2 and bag1 intrafusal myofibers began to express a slow-tonic myosin isoform not expressed by extrafusal fibers, and ceased to express some of the MHC isoforms present initially. Myotubes which eventually matured into chain fibers expressed initially both the slow-twitch and fast-twitch MHC isoforms similar to some secondary extrafusal myotubes. In contrast, adult chain fibers expressed the fast-twitch MHC isoform only. Hence intrafusal myotubes initially expressed no unique MHCs, but rather expressed MHCs similar to those expressed by extrafusal myotubes at the same chronological stage of muscle development. These observations suggest that both intrafusal and extrafusal fibers develop from common pools of bipotential myotubes. Differences in MHC expression observed between intrafusal and extrafusal fibers of rat muscle might then result from a morphogenetic effect of afferent innervation on intrafusal myotubes.
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