Evidence map›Paper›PMID 23290446›Full record

ArticleJournal of the International Neuropsychological Society : JINS2013

Major depressive disorder, cognitive symptoms, and neuropsychological performance among ethnically diverse HIV+ men and women.

Robert P Fellows, Desiree A Byrd, Susan Morgello, Manhattan HIV Brain Bank

Abstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  12. Article
  13. Factors associated with depression among HIV/AIDS children in China.International journal of mental health systems · 2019
    Article
  14. East African HIV care: depression and HIV outcomes.Global mental health (Cambridge, England) · 2019
    Article
  15. Associations between Depressive Symptomatology and Neurocognitive Impairment in HIV/AIDS.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. HIV-Associated Neurocognitive Disorders: A Global Perspective.Journal of the International Neuropsychological Society : JINS · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Robert P FellowsDepartment of Neurology, The Mount Sinai Medical Center, New York, NY, USA. robert.fellows@mssm.edu
Desiree A Byrd
Susan Morgello
Manhattan HIV Brain Bank
Mount Sinai Medical Center · USMount Sinai Hospital · US

Funding

MOUNT SINAI INSTITUTES FOR CLINICAL AND TRANSLATIONAL SCIENCESUL1RR029887 · NCRR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAMPSON, HUGH A · 2009 to 2011
$19.2M
The Manahattan HIV Brain BankR24MH059724 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MORGELLO, SUSAN · 1998 to 2007
$15.4M
The Manhattan HIV Brain BankU24MH100931 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORGELLO, SUSAN · 2013 to 2023
$14.0M
The Manhattan HIV Brain BankU01MH083501 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORGELLO, SUSAN · 2008 to 2012
$8.9M
NCRR NIH HHS UL1 RR029887NCRR NIH HHS UL1RR029887NIMH NIH HHS R24 MH059724NIMH NIH HHS U01 MH083501NIMH NIH HHS U01MH083501NIMH NIH HHS U24 MH100931
6 · The paper itself

Abstract

Major depressive disorder (MDD), cognitive symptoms, and mild cognitive deficits commonly occur in HIV-infected individuals, despite highly active antiretroviral therapies. In this study, we compared neuropsychological performance and cognitive symptoms of 191 HIV-infected participants. Results indicated that participants with a formal diagnosis of current MDD performed significantly worse than participants without MDD in all seven neuropsychological domains evaluated, with the largest effect sizes in information processing speed, learning, and memory. In addition, a brief assessment of cognitive symptoms, derived from a comprehensive neuromedical interview, correlated significantly with neurocognitive functioning. Participants with MDD reported more cognitive symptoms and showed greater neurocognitive deficits than participants without MDD. These findings indicate that HIV-infected adults with MDD have more cognitive symptoms and worse neuropsychological performance than HIV-infected individuals without MDD. The results of this study have important implications for the diagnosis of HIV-associated neurocognitive disorders (HAND).

Indexed as

AdultAnalysis of VarianceCD4 AntigensCell CountChi-Square DistributionCognition DisordersFemaleHIV InfectionsHumansMajor Depressive DisorderMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesCD4 Antigens

Identifiers

PMID23290446
PMCPMC3785228
OpenAlexW2166998161

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.