Evidence map›Paper›PMID 23290018›Full record

Trial reportPediatric neurology2013

Genetic risk factors for perinatal arterial ischemic stroke.

Amy A Gelfand, Lisa A Croen, Anthony R Torres, Yvonne W Wu

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Apolipoprotein EDisease markers · 2022
    Pooled it
  2. Pooled it
  3. Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Review
  9. Fetal intracranial hemorrhage in a case of 16p microdeletion.Case reports in perinatal medicine · 2022
    Article
  10. MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021
    Article
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Amy A GelfandDepartment of Neurology, University of California at San Francisco, San Francisco, California, USA. GelfandA@neuropeds.ucsf.edu
Lisa A Croen
Anthony R Torres
Yvonne W Wu
University of California, San Francisco · USKaiser Permanente · USUtah State University · US

Funding

Inflammation and Cerebral Palsy in Term InfantsK02NS046688 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WU, YVONNE W · 2005 to 2009
$784k
NINDS NIH HHS K02 NS046688NINDS NIH HHS K02 NS46688
6 · The paper itself

Abstract

The cause of perinatal arterial ischemic stroke is unknown in most cases. We explored whether genetic polymorphisms modify the risk of perinatal arterial ischemic stroke. In a population-based case-control study of 1997-2002 births at Kaiser Permanente Northern California, we identified 13 white infants with perinatal arterial ischemic stroke. Control subjects included 86 randomly selected white infants. We genotyped polymorphisms in nine genes involved in inflammation, thrombosis, or lipid metabolism previously linked with stroke, and compared genotype frequencies in case and control individuals. We tested several polymorphisms: tumor necrosis factor-α -308, interleukin-6, lymphotoxin A, factor V Leiden, methyltetrahydrofolate reductase 1298 and 667, prothrombin 20210, and apolipoprotein E ε2 and ε4 alleles. Patients with perinatal arterial ischemic stroke were more likely than control subjects to demonstrate at least one apolipoprotein E ε4 allele (54% vs 25%, P = 0.03). More patients with perinatal arterial ischemic stroke carried two ε4 alleles than did control subjects (15% vs 2%, P = 0.09), although this finding lacked statistical significance. Proinflammatory and prothrombotic polymorphisms were not associated with perinatal arterial ischemic stroke. The apolipoprotein E polymorphism may confer genetic susceptibility for perinatal arterial ischemic stroke. Larger population-based studies are required to confirm this finding.

Indexed as

Genetic Predisposition to DiseaseAdultApolipoproteins EArterial Occlusive DiseasesCaliforniaCase-Control StudiesFactor VFemaleGene FrequencyGenotypeHumansInfantLymphotoxin-alphaMalePolymorphism, Single NucleotidePregnancyApolipoproteins EFactor Vfactor V LeidenLymphotoxin-alphaProthrombinTumor Necrosis Factor-alpha

Identifiers

PMID23290018
PMCPMC3539155
OpenAlexW2046112840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.