ArticleScientific reports2013
Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 105 citations in OpenAlex.
- AAngewandte Chemie (International ed. in English) · 2026Article
- Assembling a new generation of radiopharmaceuticals with supramolecular theranostics.Nature reviews. Chemistry · 2024Review
- Article
- Recent Advances in Functional Nanomaterials for Diagnostic and Sensing Using Self-Assembled Monolayers.International journal of molecular sciences · 2023Review
- Metal-Assembled Collagen Peptide Microflorettes as Magnetic Resonance Imaging Agents.Molecules (Basel, Switzerland) · 2023Article
- Unprecedented Relaxivity Gap in pH-Responsive FeAngewandte Chemie (International ed. in English) · 2023Article
- Self-Assembling Peptides: From Design to Biomedical Applications.International journal of molecular sciences · 2021Review
- Peptide-Assisted Nucleic Acid Delivery Systems on the Rise.International journal of molecular sciences · 2021Review
- The Tumor Proteolytic Landscape: A Challenging Frontier in Cancer Diagnosis and Therapy.International journal of molecular sciences · 2021Review
- Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging.Journal of the American Chemical Society · 2019Article
- In-depth Study of a Novel Class of Ditopic Gadolinium(III)-based MRI Probes Sensitive to Zwitterionic Neurotransmitters.Frontiers in chemistry · 2019Article
- Deciphering the Biochemical Pathway and Pharmacokinetic Study of Amyloid βeta-42 with Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Using Systems Biology Approach.Molecular neurobiology · 2018Article
- Activatable interpolymer complex-superparamagnetic iron oxide nanoparticles as magnetic resonance contrast agents sensitive to oxidative stress.Colloids and surfaces. B, Biointerfaces · 2017Article
- Self-assembling peptide-based building blocks in medical applications.Advanced drug delivery reviews · 2017Review
- Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging.Nanotheranostics · 2017Article
- A Microfluidic Platform to design crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for enhanced MRI.Scientific reports · 2016Article
- Magnetite nanoparticles for nonradionuclide brachytherapy.Journal of applied crystallography · 2015Article
- Nanoimaging in cardiovascular diseases: Current state of the art.The Indian journal of medical research · 2015Review
- Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene.Advanced materials (Deerfield Beach, Fla.) · 2015Article
- Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging.International journal of nanomedicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein we developed a new "smart" Gd-based MR contrast agent (i.e., 1) which is susceptive to furin, a protease overexpressed in tumor. Under the action of furin, 1 condenses to form dimers (1-Ds) and the latter self-assemble into gadolinium nanparticles (Gd-NPs). Relaxivity of 1-D is more than 2 folds of those of 1 and magnevist at 1.5 T, and 1.4 folds of that of 1 at 3 T. Intracellular condensation of 1 in furin-overexpressed MDA-MB-468 cells was proven with direct two-photon laser microscopy (TPLM) fluorescence imaging of the cells incubated with the europium analog of 1 (i.e., 2). Intracellular Gd-NPs of 1 were uncovered and characterized for the first time. MRI of MDA-MB-468 tumors showed that 1 has enhanced MR contrast within the tumors than that of its scrambled control 1-Scr.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.