ArticleSleep2013
Reduced sleep and low adenosinergic sensitivity in cacna1a R192Q mutant mice.
Article in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
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- Sleep Deprivation Does not Change the Flash Electroretinogram in Wild-type andJournal of biological rhythms · 2022Article
- Sleep Disorders and Headache: A Review of Correlation and Mutual Influence.Pain and therapy · 2020Review
- Sleep Network Deterioration as a Function of Dim-Light-At-Night Exposure Duration in a Mouse Model.Clocks & sleep · 2020Article
- Caffeine does not affect susceptibility to cortical spreading depolarization in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Mouse Models of Familial Hemiplegic Migraine for Studying Migraine Pathophysiology.Current neuropharmacology · 2019Review
- Effects of chronic caffeine consumption on sleep and the sleep electroencephalogram in mice.Journal of psychopharmacology (Oxford, England) · 2019Article
- REV-ERBβ is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009.Biochemical pharmacology · 2018Article
- How Old Is Your Brain? Slow-Wave Activity in Non-rapid-eye-movement Sleep as a Marker of Brain Rejuvenation After Long-Term Exercise in Mice.Frontiers in aging neuroscience · 2018Article
- Identifying pathways modulating sleep duration: from genomics to transcriptomics.Scientific reports · 2017Article
- Differences in electroencephalographic non-rapid-eye movement sleep slow-wave characteristics between young and old mice.Scientific reports · 2017Article
- Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions.Purinergic signalling · 2016Article
- Cacna1c (Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery.Sleep · 2015Article
- Calcium channels and synaptic transmission in familial hemiplegic migraine type 1 animal models.Biophysical reviews · 2014Review
- Circadian rhythms and mood: opportunities for multi-level analyses in genomics and neuroscience: circadian rhythm dysregulation in mood disorders provides clues to the brain's organizing principles, and a touchstone for genomics and neuroscience.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- The Role of Genes in the Insomnia Phenotype.Sleep medicine clinics · 2013Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesAdenosine modulates sleep via A(1) and A(2A) receptors. As the A(1) receptor influences Ca(V)2.1 channel functioning via G-protein inhibition, there is a possible role of the Ca(V)2.1 channel in sleep regulation. To this end we investigated transgenic Cacna1a R192Q mutant mice that express mutant Ca(V)2.1 channels that are less susceptible to inhibition by G-proteins. We hypothesized that Cacna1a R192Q mice could show reduced susceptibility to adenosine, which may result in a sleep phenotype characterized by decreased sleep.
designR192Q mutant and littermate wild-type mice were subjected to a 6-h sleep deprivation, treatment with caffeine (a non-specific adenosine receptor antagonist which induces waking), or cyclopentyladenosine (CPA, an A(1) receptor specific agonist which induces sleep). MEASUREMENTS AND
resultsUnder baseline conditions, Cacna1a R192Q mice showed more waking with longer waking episodes in the dark period and less non-rapid eye movement (NREM) sleep, but equal amounts of REM sleep compared to wild-type. After treatment with caffeine R192Q mice initiated sleep 30 min earlier than wild-type, whereas after CPA treatment, R192Q mice woke up 260 min earlier than wild-type. Both results indicate that Cacna1a R192Q mice are less susceptible to adenosinergic input, which may explain the larger amount of waking under undisturbed baseline conditions.
conclusionWe here show that adenosinergic sleep induction, and responses to caffeine and CPA, are modified in the R192Q mutant in a manner consistent with decreased susceptibility to inhibition by adenosine. The data suggest that the A(1) receptor modulates sleep via the Ca(V)2.1 channel.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.