ArticleSleep2013
Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy.
Article in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Peripheral vs. core body temperature as hypocretin/orexin neurons degenerate: Exercise mitigates increased heat loss.Peptides · 2023Article
- Progress of autonomic disturbances in narcolepsy type 1.Frontiers in neurology · 2023Review
- Orexin, Sleep, Sympathetic Neural Activity, and Cardiovascular Function.Hypertension (Dallas, Tex. : 1979) · 2022Review
- Body Weight and Metabolic Rate Changes in Narcolepsy: Current Knowledge and Future Directions.Metabolites · 2022Review
- Disrupted nighttime sleep and sleep instability in narcolepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Review
- Effect of Sleep Disorders on Blood Pressure and Hypertension in Children.Current hypertension reports · 2020Review
- Prolonged Waking and Recovery Sleep Affect the Serum MicroRNA Expression Profile in Humans.Clocks & sleep · 2019Article
- The link between narcolepsy and autonomic cardiovascular dysfunction: a translational perspective.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Challenges in the development of therapeutics for narcolepsy.Progress in neurobiology · 2017Review
- Role of Orexin-A in Hypertension and Obesity.Current hypertension reports · 2017Review
- Normal Morning Melanin-Concentrating Hormone Levels and No Association with Rapid Eye Movement or Non-Rapid Eye Movement Sleep Parameters in Narcolepsy Type 1 and Type 2.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017Article
- The relationship between orexin levels and blood pressure changes in patients with narcolepsy.PloS one · 2017Article
- Direct projections from hypothalamic orexin neurons to brainstem cardiac vagal neurons.Neuroscience · 2016Article
- Article
- The diagnostic value of power spectra analysis of the sleep electroencephalography in narcoleptic patients.Sleep medicine · 2015Article
- Dysautonomia in narcolepsy: evidence by questionnaire assessment.Journal of clinical neurology (Seoul, Korea) · 2014Article
- Article
- Prevalence of periodical leg movements in patients with narcolepsy in an outpatient facility in São Paulo.Sleep science (Sao Paulo, Brazil) · 2014Article
- Orexin, orexin receptor antagonists and central cardiovascular control.Frontiers in neuroscience · 2013Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveSeveral studies have suggested that hypocretin-1 may influence the cerebral control of the cardiovascular system. We analyzed whether hypocretin-1 deficiency in narcolepsy patients may result in a reduced heart rate response.
designWe analyzed the heart rate response during various sleep stages from a 1-night polysomnography in patients with narcolepsy and healthy controls. The narcolepsy group was subdivided by the presence of +/- cataplexy and +/- hypocretin-1 deficiency.
settingSleep laboratory studies conducted from 2001-2011.
participantsIn total 67 narcolepsy patients and 22 control subjects were included in the study. Cataplexy was present in 46 patients and hypocretin-1 deficiency in 38 patients.
interventionsNone. MEASUREMENTS AND
resultsAll patients with narcolepsy had a significantly reduced heart rate response associated with arousals and leg movements (P < 0.05). Heart rate response associated with arousals was significantly lower in the hypocretin-1 deficiency and cataplexy groups compared with patients with normal hypocretin-1 levels (P < 0.04) and patients without cataplexy (P < 0.04). Only hypocretin-1 deficiency significantly predicted the heart rate response associated with arousals in both REM and non-REM in a multivariate linear regression.
conclusionsOur results show that autonomic dysfunction is part of the narcoleptic phenotype, and that hypocretin-1 deficiency is the primary predictor of this dysfunction. This finding suggests that the hypocretin system participates in the modulation of cardiovascular function at rest.
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