ArticleThe journal of physiological sciences : JPS2013
The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice.
Article in The journal of physiological sciences : JPS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Cardiac Regenerative Potential of Spiny Mice (Acomys cahirinus) Manifests Itself in Expansion of Pacemaker Myocardium and Predominance of Noncanonical, IDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2025Article
- Investigating the effect of cholinergic and adrenergic blocking agents on maternal-fetal heart rates and their interactions in mice fetuses.Biology open · 2022Article
- The role of M3 receptors in regulation of electrical activity deteriorates in the rat heart during ageing.Current research in physiology · 2022Article
- Phosphodiesterases Expression during Murine Cardiac Development.International journal of molecular sciences · 2021Article
- Mitogen-activated protein kinase p38 modulates pacemaker ion channels differentiation in P19-derived pluripotent cells.The journal of physiological sciences : JPS · 2020Article
- Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans.Frontiers in physiology · 2020Review
- Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study.Frontiers in physiology · 2020Article
- Part and Parcel of the Cardiac Autonomic Nerve System: Unravelling Its Cellular Building Blocks during Development.Journal of cardiovascular development and disease · 2016Review
- The destiny of Ca(2+) released by mitochondria.The journal of physiological sciences : JPS · 2015Review
- Stable, covalent attachment of laminin to microposts improves the contractility of mouse neonatal cardiomyocytes.ACS applied materials & interfaces · 2014Article
- Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.The Journal of clinical investigation · 2014Article
- The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice.The journal of physiological sciences : JPS · 2013Article
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7 authors.
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Abstract
Heart rate (HR) of mammalian species changes postnatally, i.e., HR of large animals including humans decreases, while HR in small animals such as mice and rats increases. To clarify cellular mechanisms underlying the postnatal HR changes, we performed in vivo HR measurement and electrophysiological analysis on sinoatrial node (SAN) cells in mice. The in vivo HR was ~320 beats min(-1) (bpm) immediately after birth, and increased with age to ~690 bpm at postnatal day 14. Under blockage of autonomic nervous systems, HR remained constant until postnatal day 5 and then increased day by day. The spontaneous beating rate of SAN preparation showed a similar postnatal change. The density of the L-type Ca(2+) current (LCC) was smaller in neonatal SAN cells than in adult cells, accompanied by a positive shift of voltage-dependent activation. Thus, the postnatal increase in HR is caused by both the increased sympathetic influence and the intrinsic activity of SAN cells. The different conductance and kinetics of LCC may be involved in the postnatal increase in pacemaker activity.
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