ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Age and exercise training alter signaling through reactive oxygen species in the endothelium of skeletal muscle arterioles.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Age-related diaphragm dysfunction: could diaphragm arteriole dysfunction be to blame?The Journal of physiology · 2025Article
- Transcapillary POJournal of vascular research · 2025Article
- Microvascular endothelial dysfunction in vascular senescence and disease.Frontiers in cardiovascular medicine · 2025Review
- Effects of Psychogenic Stress Frequency during the Growth Stage on Oxidative Stress, Organ and Bone Development.Journal of bone metabolism · 2024Article
- Exercise induces superoxide and NOX4 contribution in endothelium-dependent dilation in coronary arterioles from a swine model of chronic myocardial ischemia.Microvascular research · 2023Article
- Ageing and endothelium-mediated vascular dysfunction: the role of the NADPH oxidases.The Journal of physiology · 2023Article
- Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats.Scientific reports · 2021Article
- Vasoconstrictor Mechanisms in Chronic Hypoxia-Induced Pulmonary Hypertension: Role of Oxidant Signaling.Antioxidants (Basel, Switzerland) · 2020Review
- Vasodilatory and vascular mitochondrial respiratory function with advancing age: evidence of a free radically mediated link in the human vasculature.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Cellular Senescence in Arterial Diseases.Journal of lipid and atherosclerosis · 2020Review
- Vasodilatory function in human skeletal muscle feed arteries with advancing age: the role of adropin.The Journal of physiology · 2019Article
- Voluntary wheel running prevents salt-induced endothelial dysfunction: role of oxidative stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function.Physiological reviews · 2019 · on this mapReview
- Microvascular mechanisms limiting skeletal muscle blood flow with advancing age.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Telomere uncapping and vascular aging.American journal of physiology. Heart and circulatory physiology · 2018Review
- Daily muscle stretching enhances blood flow, endothelial function, capillarity, vascular volume and connectivity in aged skeletal muscle.The Journal of physiology · 2018Article
- Effects of age and exercise training on coronary microvascular smooth muscle phenotype and function.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Exercise training reverses age-induced diastolic dysfunction and restores coronary microvascular function.The Journal of physiology · 2017Article
- Intermittent parathyroid hormone administration attenuates endothelial dysfunction in old rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice.Aging · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Exercise training ameliorates age-related impairments in endothelium-dependent vasodilation in skeletal muscle arterioles. Additionally, exercise training is associated with increased superoxide production. The purpose of this study was to determine the role of superoxide and superoxide-derived reactive oxygen species (ROS) signaling in mediating endothelium-dependent vasodilation of soleus muscle resistance arterioles from young and old, sedentary and exercise-trained rats. Young (3 mo) and old (22 mo) male rats were either exercise trained or remained sedentary for 10 wk. To determine the impact of ROS signaling on endothelium-dependent vasodilation, responses to acetylcholine were studied under control conditions and during the scavenging of superoxide and/or hydrogen peroxide. To determine the impact of NADPH oxidase-derived ROS, endothelium-dependent vasodilation was determined following NADPH oxidase inhibition. Reactivity to superoxide and hydrogen peroxide was also determined. Tempol, a scavenger of superoxide, and inhibitors of NADPH oxidase reduced endothelium-dependent vasodilation in all groups. Similarly, treatment with catalase and simultaneous treatment with tempol and catalase reduced endothelium-dependent vasodilation in all groups. Decomposition of peroxynitrite also reduced endothelium-dependent vasodilation. Aging had no effect on arteriolar protein content of SOD-1, catalase, or glutathione peroxidase-1; however, exercise training increased protein content of SOD-1 in young and old rats, catalase in young rats, and glutathione peroxidase-1 in old rats. These data indicate that ROS signaling is necessary for endothelium-dependent vasodilation in soleus muscle arterioles, and that exercise training-induced enhancement of endothelial function occurs, in part, through an increase in ROS signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.