Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013
Periodontal status and bacteremia with oral viridans streptococci and coagulase negative staphylococci in allogeneic hematopoietic stem cell transplantation recipients: a prospective observational study.
Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Systemic implications of endodontic and periodontal infections in hematopoietic stem cell transplantation: a systematic review.Clinical oral investigations · 2025Pooled it
- Definitions used for a healthy periodontium-A systematic review.International journal of dental hygiene · 2020Pooled it
- Improving Oral Health and Modulating the Oral Microbiome to Reduce Bloodstream Infections from Oral Organisms in Pediatric and Young Adult Hematopoietic Stem Cell Transplantation Recipients: A Randomized Controlled Trial.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020Trial
- Token economy to improve adherence to activities of daily living.Pediatric blood & cancer · 2018Trial
- Risk factors and clinical outcomes of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a retrospective study of 551 cases.BMC oral health · 2026Article
- Beyond Oral Health: Personalized Strategies for Managing Oral Infections in Neutropenic Patients.Journal of personalized medicine · 2026Review
- The effect of conditioning regimen intensity on periodontal health in haematopoietic cell transplantation recipients: a 5-year multicentre prospective cohort study.Clinical oral investigations · 2025Article
- Assessment of prophylactic antibiotics protocols in paediatric dental treatment under general anaesthesia in two Saudi-Arabian Hospitals: a quasi-study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Influence of periodontal status on patients undergoing hematopoietic stem cell transplantation: A retrospective analysis.Heliyon · 2024Article
- Dental evaluation and clearance prior to allogeneic hematopoietic cell transplantation.Oral diseases · 2024Article
- Oral microbial changes and oral disease management before and after the treatment of hematological malignancies: a narrative review.Clinical oral investigations · 2023Review
- The oral microbiome in the pathophysiology of cardiovascular disease.Nature reviews. Cardiology · 2023Review
- General Factors and Dental-Related Risk Factors for Postoperative Pneumonia or Infectious Complications: A Retrospective Study.Journal of clinical medicine · 2023Article
- Oral health in patients scheduled for hematopoietic stem cell transplantation in the Orastem study.PloS one · 2023Observational
- Clinical utility of oral management in allogeneic hematopoietic stem cell transplantation recipients: microbiological evidence based on molecular analysis of oral bacteria.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Intensive oral care can reduce bloodstream infection with coagulase-negative staphylococci after neutrophil engraftment in allogeneic hematopoietic stem-cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Proposed protocol for treatment of severe periodontitis without platelet transfusion in patients with aplastic anemia: a case report.Journal of medical case reports · 2021Article
- Predictive factors for dental inflammation with exacerbation during cancer therapy with FDG-PET/CT imaging.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Oral microorganisms and bloodstream infection in allogeneic hematopoietic stem cell transplantation.Clinical oral investigations · 2021Article
- Dental status and risk of odontogenic complication in patients undergoing hematopoietic stem cell transplant.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study was aimed to investigate whether any association could be found between the presence of an inflamed and infected periodontium (e.g., gingivitis and periodontitis) and the development of bacteremia during neutropenia following allogeneic hematopoietic stem cell transplantation (HSCT).
methodsEighteen patients underwent a periodontal examination before HSCT. Patients were classified as periodontally healthy [all periodontal pocket depths (PPD) ≤ 4 mm and bleeding on probing (BOP) ≤ 10%) or as having gingivitis/periodontitis (PPD ≥ 4 mm and BOP > 10%]. Oral mucositis (OM) was scored using the daily mucositis score. Blood cultures were taken at least twice weekly.
resultsFive patients were periodontally healthy, while 13 patients had gingivitis or periodontitis. Twelve patients (67%) developed bacteremia during neutropenia, of which 11 patients (61%) had one or more episodes of bacteremia due to coagulase-negative staphylococci (CONS, most often Staphylococcus epidermidis) or to oral viridans streptococci (OVS), or both. Patients with gingivitis/periodontitis more often had bacteremia than those with a healthy periodontium (p = 0.047), and BOP was associated with bacteremia (p = 0.049). All patients developed ulcerative OM, but its severity and duration were not associated with bacteremia. OM duration and the length of stay in the hospital were strongly correlated (R = 0.835, p ≤ 0.001).
conclusionThis study indicates that periodontal infections may contribute to the risk of developing OVS and CONS bacteremia during neutropenia following HSCT. While our results point to the importance of periodontal evaluation and management before HSCT, further studies on periodontal contribution to systemic infectious complications are warranted.
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