Evidence map›Paper›PMID 23288379›Full record

ArticleJournal of general internal medicine2013

Key barriers to medication adherence in survivors of strokes and transient ischemic attacks.

Ian M Kronish, Michael A Diefenbach, Donald E Edmondson, L Alison Phillips, Kezhen Fei, Carol R Horowitz

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of general internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01027273 (Preventing Recurrence of All Inner-city Strokes Through Education), which is not on this map. Cited by 44 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 7 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01027273 nacompletednot on this map

Preventing Recurrence of All Inner-city Strokes Through Education

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2009 to 2013Enrolled600ConditionsStroke Recurrence, Transient Ischemic AttackArmsPrevent Return of Stroke
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 7 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Psychological Determinants of Medication Adherence in Stroke Survivors: a Systematic Review of Observational Studies.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2017
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Recurrent stroke admissions withWorld journal of virology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ian M KronishCenter for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY, USA. Ik2293@columbia.edu
Michael A Diefenbach
Donald E Edmondson
L Alison Phillips
Kezhen Fei
Carol R Horowitz
Icahn School of Medicine at Mount Sinai · USColumbia University Irving Medical Center · USGeorge Washington University · US

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
MOUNT SINAI INSTITUTES FOR CLINICAL AND TRANSLATIONAL SCIENCESUL1RR029887 · NCRR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MURPHY, BARBARA T. · 2009 to 2011
$19.2M
Mount Sinai Institutes for Clinical and Translational SciencesUL1TR000067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAMPSON, HUGH A · 2012 to 2014
$16.5M
RESEARCH COREP60MD000270 · NIMHD · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BICKELL, NINA A. · 2002 to 2011
$15.1M
Uncontrolled hypertension - the role of medication adherence and clinical inertiaK23HL098359 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRONISH, IAN MATTHEW · 2010 to 2014
$688k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000067NCRR NIH HHS UL1 RR029887NCRR NIH HHS UL1RR029887NHLBI NIH HHS K23 HL098359NIMHD NIH HHS P60 MD000270NIMHD NIH HHS P60MD00270
6 · The paper itself

Abstract

backgroundEven though medications can greatly reduce the risk of recurrent stroke, medication adherence is suboptimal in stroke survivors.

objectiveTo identify key barriers to medication adherence in a predominantly low-income, minority group of stroke and transient ischemic attack (TIA) survivors.

designCross-sectional study.

participantsSix hundred stroke or TIA survivors, age ≥ 40 years old, recruited from underserved communities in New York City. MAIN MEASURES: Medication adherence was measured using the 8-item Morisky Medication Adherence Questionnaire. Potential barriers to adherence were assessed using validated instruments. Logistic regression was used to test which barriers were independently associated with adherence. Models were additionally controlled for age, race/ethnicity, income, and comorbidity. KEY

resultsForty percent of participants had poor self-reported medication adherence. In unadjusted analyses, compared to adherent participants, non-adherent participants had increased concerns about medications (26 % versus 7 %, p < 0.001), low trust in their personal doctor (42 % versus 29 %, p = 0.001), problems communicating with their doctor due to language (19 % versus 12 %, p = 0.02), perceived discrimination from the health system (42 % versus 22 %, p < 0.001), difficulty accessing health care (16 % versus 8 %, p = 0.002), and inadequate continuity of care (27 % versus 20 %, p = 0.05). In the fully adjusted model, only increased concerns about medications [OR 5.02 (95 % CI 2.76, 9.11); p < 0.001] and perceived discrimination [OR 1.85 (95 % CI 1.18, 2.90); p = 0.008] remained significant barriers.

conclusionsIncreased concerns about medications (related to worry, disruption, long-term effects, and medication dependence) and perceived discrimination were the most important barriers to medication adherence in this group. Interventions that reduce medication concerns have the greatest potential to improve medication adherence in low-income stroke/TIA survivors.

Indexed as

Drug MonitoringAdultAgedCross-Sectional StudiesFemaleHealth Knowledge, Attitudes, PracticeHealth Services AccessibilityHumansIschemic Attack, TransientMaleMedically Underserved AreaMedication AdherenceMiddle AgedNew York CityProfessional-Patient RelationsPsychometrics

Identifiers

PMID23288379
PMCPMC3631079
OpenAlexW1989870611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.