ArticleEuropean journal of nuclear medicine and molecular imaging2013
Blood flow, flow reserve, and glucose utilization in viable and nonviable myocardium in patients with ischemic cardiomyopathy.
Article in European journal of nuclear medicine and molecular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Assessment of resting myocardial blood flow in regions of known transmural scar to confirm accuracy and precision of 3D cardiac positron emission tomography.EJNMMI research · 2023Article
- Absolute RestingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Assessment of cerebral glucose metabolism in patients with heart failure byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Myocardial stunning and hibernation revisited.Nature reviews. Cardiology · 2021Review
- Wireless Technologies for Implantable Devices.Sensors (Basel, Switzerland) · 2020Review
- Clinical significance of quantitative assessment of glucose utilization in patients with ischemic cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Clinical significance of quantitative assessment of right ventricular glucose metabolism in patients with heart failure with reduced ejection fraction.European journal of nuclear medicine and molecular imaging · 2019Article
- Imaging of myocardial fatty acid oxidation.Biochimica et biophysica acta · 2016Review
- Molecular and cellular basis of viable dysfunctional myocardium.Circulation. Heart failure · 2014Review
- Myocardial perfusion reserve in spared myocardium: one more tessera of the complex mosaic of LV remodelling after myocardial infarction.European journal of nuclear medicine and molecular imaging · 2013Article
- Incidental Detection of NSTEMI on Whole-body [Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeThe aim of the study was to determine whether glucose uptake in viable myocardium of ischemic cardiomyopathy patients depends on rest myocardial blood flow (MBF) and the residual myocardial flow reserve (MFR).
methodsThirty-six patients with ischemic cardiomyopathy (left ventricular ejection fraction 25 ± 10 %) were studied with (13)N-ammonia and (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET). Twenty age-matched normals served as controls. Regional MBF was determined at rest and during dipyridamole hyperemia and regional FDG extraction was estimated from regional FDG to (13)N-ammonia activity ratios.
resultsRest MBF was reduced in viable (0.42 ± 0.18 ml/min per g) and nonviable regions (0.32 ± 0.09 ml/min per g) relative to remote regions (0.68 ± 0.23 ml/min per g, p < 0.001) and to normals (0.63 ± 0.13 ml/min per g). Dipyridamole raised MBFs in controls, remote, viable, and nonviable regions. MBFs at rest (p < 0.05) and stress (p < 0.05) in viable regions were significantly higher than that in nonviable regions, while MFRs did not differ significantly (p > 0.05). Compared to MFR in remote myocardium, MFRs in viable regions were similar (1.39 ± 0.56 vs 1.70 ± 0.45, p > 0.05) but were significantly lower in nonviable regions (1.23 ± 0.43, p < 0.001). Moreover, the FDG and thus glucose extraction was higher in viable than in remote (1.40 ± 0.14 vs 0.90 ± 0.20, p < 0.001) and in nonviable regions (1.13 ± 0.21, p < 0.001). The extraction of FDG in viable regions was independent of rest MBF but correlated inversely with MFRs (r =-0.424, p < 0.05). No correlation between the FDG extraction and MFR was observed in nonviable regions.
conclusionAs in the animal model, decreasing MFRs in viable myocardium are associated with increasing glucose extraction that likely reflects a metabolic adaptation of remodeling hibernating myocytes.
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