Evidence map›Paper›PMID 23287972›Full record

ReviewJournal of neurology2013

Selecting deep brain stimulation or infusion therapies in advanced Parkinson's disease: an evidence-based review.

Jens Volkmann, Alberto Albanese, Angelo Antonini, K Ray Chaudhuri, Carl E Clarke, Rob M A de Bie, Günther Deuschl, Karla Eggert, Jean-Luc Houeto, Jaime Kulisevsky and 14 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 6 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 6 syntheses or guidelines pooled it, 148 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Intrajejunal Infusion of Levodopa/Carbidopa for Advanced Parkinson's Disease: A Systematic Review.Movement disorders : official journal of the Movement Disorder Society · 2021
    Pooled it
  4. Translating Evidence to Advanced Parkinson's Disease Patients: A Systematic Review and Meta-Analysis.Movement disorders : official journal of the Movement Disorder Society · 2021
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Effect of levodopa-carbidopa intestinal gel on dyskinesia in advanced Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society · 2016
    Trial
  10. Article
  11. Refractory Motor Complications: Towards a Pragmatic Definition.Movement disorders clinical practice · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 20 institutions in 13 countries.

Jens VolkmannDepartment of Neurology, University Clinic of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany, volkmann_j@klinik.uni-wuerzburg.de.
Alberto Albanese
Angelo Antonini
K Ray Chaudhuri
Carl E Clarke
Rob M A de Bie
Günther Deuschl
Karla Eggert
Jean-Luc Houeto
Jaime Kulisevsky
Dag Nyholm
Per Odin
Karen Østergaard
Werner Poewe
Pierre Pollak
Jose Martin Rabey
Olivier Rascol
Evzen Ruzicka
Michael Samuel
Hans Speelman
Olof Sydow
Francesc Valldeoriola
Chris van der Linden
Wolfgang Oertel
King's College Hospital · GBPhilipps University of Marburg · DEAarhus University Hospital · DKAmsterdam UMC Location University of Amsterdam · NLAssaf Harofeh Medical Center · ILBirmingham Dental Hospital · GBCentre Hospitalier Universitaire de Poitiers · FRCharles University · CZChristian-Albrechts-Universität zu Kiel · DEHôpital Beau-Séjour · CHHospital Clínic de Barcelona · ESInnsbruck Medical University · ATInserm · FRIRCCS San Camillo Hospital · ITKarolinska University Hospital · SEKlinikum Bremerhaven-Reinkenheide · DELucas Research · USUniversità Cattolica del Sacro Cuore · ITUniversitat Autònoma de Barcelona · ESUniversity of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motor complications in Parkinson's disease (PD) result from the short half-life and irregular plasma fluctuations of oral levodopa. When strategies of providing more continuous dopaminergic stimulation by adjusting oral medication fail, patients may be candidates for one of three device-aided therapies: deep brain stimulation (DBS), continuous subcutaneous apomorphine infusion, or continuous duodenal/jejunal levodopa/carbidopa pump infusion (DLI). These therapies differ in their invasiveness, side-effect profile, and the need for nursing care. So far, very few comparative studies have evaluated the efficacy of the three device-aided therapies for specific motor problems in advanced PD. As a result, neurologists currently lack guidance as to which therapy could be most appropriate for a particular PD patient. A group of experts knowledgeable in all three therapies reviewed the currently available literature for each treatment and identified variables of clinical relevance for choosing one of the three options such as type of motor problems, age, and cognitive and psychiatric status. For each scenario, pragmatic and (if available) evidence-based recommendations are provided as to which patients could be candidates for either DBS, DLI, or subcutaneous apomorphine.

Indexed as

Deep Brain StimulationAntiparkinson AgentsApomorphineCarbidopaDrug Administration RoutesEvidence-Based PracticeHumansLevodopaParkinson DiseaseAntiparkinson AgentsApomorphineCarbidopaLevodopa

Identifiers

PMID23287972
PMCPMC3825542
OpenAlexW2136618376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.