ArticleInvestigative ophthalmology & visual science2013
Basal blood flow and autoregulation changes in the optic nerve of rhesus monkeys with idiopathic bilateral optic atrophy.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Optic nerve head and retinal blood flow regulation during isometric exercise as assessed with laser speckle flowgraphy.PloS one · 2017Trial
- Eye Tracking Parameters Correlate with the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study.Advances in experimental medicine and biology · 2022Article
- International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (Journal of toxicologic pathology · 2021Review
- Peripapillary Retinoschisis in Glaucoma: Association With Progression and OCT Signs of Müller Cell Involvement.Investigative ophthalmology & visual science · 2018Article
- Morphometric Analysis of Peripapillary Thickness in Hypertensives and Normotensives using Optical Coherence Tomography (OCT).Journal of clinical and diagnostic research : JCDR · 2016Article
- Compromised Optic Nerve Blood Flow and Autoregulation Secondary to Neural Degeneration.Investigative ophthalmology & visual science · 2015Article
- Longitudinal hemodynamic changes within the optic nerve head in experimental glaucoma.Investigative ophthalmology & visual science · 2013Article
- Optic nerve head blood flow autoregulation during changes in arterial blood pressure in healthy young subjects.PloS one · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo characterize the hemodynamic features and the association with structural damage in the optic nerve head (ONH) of idiopathic bilateral optic atrophy (BOA) in rhesus macaque monkeys.
methodsIn five animals with BOA and nine healthy animals under general anesthesia (pentobarbital), intraocular pressure (IOP) was manometrically controlled. ONH blood flow was measured with a laser speckle flow graph device. Basal blood flow in global and quadrantal sectors was measured with IOP set at 10 mm Hg; autoregulation capacity was assessed by comparing blood flow changes before and after IOP was increased from 10 to 30 mm Hg. Spectral-domain optic coherence tomography was used to measure retinal nerve fiber layer thickness (RNFLT) by peripapillary circular scans.
resultsCompared with control eyes, RNFLT in BOA eyes was significantly less in all sectors (P < 0.001) except the nasal (P = 0.25); the average global and sectoral blood flow in all quadrants was significantly lower (P < 0.001). These blood flow changes were significantly correlated with corresponding sectoral RNFLT (P < 0.01) except the nasal (P = 0.25). After IOP was increased to 30 mm Hg, global blood flow was significantly reduced (P < 0.001), but with no regional preferences despite prominent temporal RNFLT loss; no significant blood flow change was observed in control eyes (P = 0.24).
conclusionsBasal blood flow and autoregulation capacity in the ONH of BOA were significantly compromised, with a close correlation to structural changes. The hemodynamic changes showed no regional preference across the ONH, which was consistent with postmortem histological observations.
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