ArticleNanomedicine (London, England)2013
Gene expression profiling and histomorphometric analyses of the early bone healing response around nanotextured implants.
Article in Nanomedicine (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 36 citations in OpenAlex.
- Topography-mediated immunomodulation in osseointegration; Ally or Enemy.Biomaterials · 2022Review
- Effects of rmBMP-7 on Osteoblastic Cells Grown on a Nanostructured Titanium Surface.Biomimetics (Basel, Switzerland) · 2022Article
- Influence of Nanotopography on Early Bone Healing during Controlled Implant Loading.Nanomaterials (Basel, Switzerland) · 2020Article
- Noninvasive Electrical Stimulation Improves Photoreceptor Survival and Retinal Function in Mice with Inherited Photoreceptor Degeneration.Investigative ophthalmology & visual science · 2020Article
- Bioactive Titanium Surfaces: Interactions of Eukaryotic and Prokaryotic Cells of Nano Devices Applied to Dental Practice.Biomedicines · 2019Article
- Vitamin E Metabolic Effects and Genetic Variants: A Challenge for Precision Nutrition in Obesity and Associated Disturbances.Nutrients · 2018Review
- Bone healing response in cyclically loaded implants: Comparing zero, one, and two loading sessions per day.Journal of the mechanical behavior of biomedical materials · 2018Article
- Surface nanocavitation of titanium modulates macrophage activity.International journal of nanomedicine · 2018Article
- Nanotopography directs mesenchymal stem cells to osteoblast lineage through regulation of microRNA-SMAD-BMP-2 circuit.Journal of cellular physiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
unlabelledWhile in vitro studies have shown that nanoscale surface modifications influence cell fate and activity, there is little information on how they modulate healing at the bone-implant interface.
aimThis study aims to investigate the effect of nanotopography at early time intervals when critical events for implant integration occur. MATERIALS &
methodsUntreated and sulfuric acid/hydrogen peroxide-treated machined-surface titanium alloy implants were placed in rat tibiae. Samples were processed for DNA microarray analysis and histomorphometry.
resultsAt both 3 and 5 days, the gene expression profile of the healing tissue around nanotextured implants differed from that around machined-surface implants or control empty holes, and were accompanied by an increase in bone-implant contact on day 5. While some standard pathways such as the immune response predominated, a number of unclassified genes were also implicated.
conclusionNanotexture elicits an initial gene response that is more complex than suspected so far and favors healing at the bone-implant interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.