ArticleMolecular cancer2013
Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion.
Article in Molecular cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 232 citations in OpenAlex.
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- Incidence of Mucinous Adenocarcinoma of the Colon in the Bangladeshi Population: A Pilot Observational Study.Cureus · 2025Article
- Analysis of extracellular vesicles of frequently used colorectal cancer cell lines.BMC cancer · 2025Article
- Presentation of Metastatic Colorectal Carcinoma at a Tertiary Care Center in Pakistan.Journal of cancer & allied specialties · 2025Article
- Identification of hub genes distinguishing subtypes in endometrial stromal sarcoma through comprehensive bioinformatics analysis.Scientific reports · 2024Article
- A Transcriptome and Methylome Study Comparing Tissues of Early and Late Onset Colorectal Carcinoma.International journal of molecular sciences · 2022Article
- Whole-genome profiling of primary cutaneous anaplastic large cell lymphoma.Haematologica · 2022Article
- SCClone: Accurate Clustering of Tumor Single-Cell DNA Sequencing Data.Frontiers in genetics · 2022Article
- FaNDOM: Fast nested distance-based seeding of optical maps.Patterns (New York, N.Y.) · 2021Article
- RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway.Molecular therapy oncolytics · 2020Article
- A Novel XGBoost Method to Identify Cancer Tissue-of-Origin Based on Copy Number Variations.Frontiers in genetics · 2020Article
- Genome-wide prediction and prioritization of human aging genes by data fusion: a machine learning approach.BMC genomics · 2019Article
- NOMO-1 gene is deleted in early-onset colorectal cancer.Oncotarget · 2017Article
- RBFOX3 Promotes Tumor Growth and Progression via hTERT Signaling and Predicts a Poor Prognosis in Hepatocellular Carcinoma.Theranostics · 2017Article
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Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundPrevalence of colorectal cancer (CRC) in the British Bangladeshi population (BAN) is low compared to British Caucasians (CAU). Genetic background may influence mutations and disease features.
methodsWe characterized the clinicopathological features of BAN CRCs and interrogated their genomes using mutation profiling and high-density single nucleotide polymorphism (SNP) arrays and compared findings to CAU CRCs.
resultsAge of onset of BAN CRC was significantly lower than for CAU patients (p=3.0 x 10-5) and this difference was not due to Lynch syndrome or the polyposis syndromes. KRAS mutations in BAN microsatellite stable (MSS) CRCs were comparatively rare (5.4%) compared to CAU MSS CRCs (25%; p=0.04), which correlates with the high percentage of mucinous histotype observed (31%) in the BAN samples. No BRAF mutations was seen in our BAN MSS CRCs (CAU CRCs, 12%; p=0.08). Array data revealed similar patterns of gains (chromosome 7 and 8q), losses (8p, 17p and 18q) and LOH (4q, 17p and 18q) in BAN and CAU CRCs. A small deletion on chromosome 16p13.2 involving the alternative splicing factor RBFOX1 only was found in significantly more BAN (50%) than CAU CRCs (15%) cases (p=0.04). Focal deletions targeting the 5' end of the gene were also identified. Novel RBFOX1 mutations were found in CRC cell lines and tumours; mRNA and protein expression was reduced in tumours.
conclusionsKRAS mutations were rare in BAN MSS CRC and a mucinous histotype common. Loss of RBFOX1 may explain the anomalous splicing activity associated with CRC.
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