ArticleEnvironmental health : a global access science source2013
Polycyclic aromatic hydrocarbon exposure and pediatric asthma in children: a case-control study.
Article in Environmental health : a global access science source, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 252 citations in OpenAlex.
- Susceptibility to childhood asthma modified by the interactive effects of polycyclic aromatic hydrocarbons exposure and genetic polymorphisms of the aryl hydrocarbon receptor signaling pathway: functional analysis based on lipid metabolism.Respiratory research · 2025Article
- [Serum levels of polycyclic aromatic hydrocarbons and health risk assessment among children and adolescents].Se pu = Chinese journal of chromatography · 2025Article
- Association between polycyclic aromatic hydrocarbons exposure and current asthma: a population-based study.BMC public health · 2025Article
- An evaluation of in utero polycyclic aromatic hydrocarbon exposure on the neonatal meconium microbiome.Environmental research · 2024Article
- Environmental Exposure and Pediatric Asthma Prevalence in Saudi Arabia: A Cross-Sectional Study.Cureus · 2023Article
- Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study.Environment international · 2022Article
- The Influence of Environmental Polycyclic Aromatic Hydrocarbons (PAHs) Exposure on DNA Damage among School Children in Urban Traffic Area, Malaysia.International journal of environmental research and public health · 2022Article
- The preliminary investigation of potential response biomarkers to PAHs exposure on childhood asthma.Journal of exposure science & environmental epidemiology · 2022Article
- Systematic Review of Exposure to Polycyclic Aromatic Hydrocarbons and Obstructive Lung Disease.Journal of health & pollution · 2021Review
- Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Health Effects of Naphthalene Exposure: A Systematic Evidence Map and Analysis of Potential Considerations for Dose-Response Evaluation.Environmental health perspectives · 2021Article
- Polycyclic aromatic hydrocarbon exposure results in altered CRH, reproductive, and thyroid hormone concentrations during human pregnancy.The Science of the total environment · 2020Article
- Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases.Respiratory research · 2020Review
- Discovery of firefighter chemical exposures using military-style silicone dog tags.Environment international · 2020Article
- Development of an environmental health tool linking chemical exposures, physical location and lung function.BMC public health · 2019Article
- Discovery of common chemical exposures across three continents using silicone wristbands.Royal Society open science · 2019Article
- Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma.Environmental geochemistry and health · 2019Review
- Exposure to polycyclic aromatic hydrocarbons, vitamin D, and lung function in children with asthma.Pediatric pulmonology · 2018Article
- 2-Naphthol Levels and Allergic Disorders in Children.International journal of environmental research and public health · 2018Article
- Urinary polycyclic aromatic hydrocarbon metabolites and adult asthma: a case-control study.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBronchial asthma is one of the most prevalent diseases in Arab children. Environmental pollution has been suggested to be considered causative of asthma, nasal symptoms and bronchitis in both children and adult. The objectives of this study were to evaluate the association between serum polycyclic aromatic hydrocarbons (PAHs) levels, asthma and allergic outcomes among Saudi children aged up to 15 yrs. We hypothesized that increased serum PAHs are associated with allergy, asthma, or respiratory symptoms.
methodsA total of 195 Saudi children (98 asthma pediatric patients and 97 healthy controls) were randomly selected from the Riyadh Cohort Study for inclusion. The diagnosis of Asthma was based on established pediatric diagnosis and medications taken.
resultsAsthma related markers showed highly significant differences between children with and without asthma. Thus IgE, resistin and IL-4 were significantly increased (p 0.004, 0.001 and 0.003, respectively) in children with asthma compared with non-asthma control subjects. GMCSF, IFN-γ, IL-5, IL-8 and IL-10, on the other hand, were significantly decreased in children with asthma (p 0.003, 0.03, 0.001, 0.004 and 0.03, respectively). Strong associations between serum PAHs levels and biomarkers of childhood asthma were detected in Arabic children. Data confirmed the role of naphthalene, 4H-cyclobenta[def]phenanthrene, 1,2-benzanthracene, chrysene and benzo(e)acephenanthrylene in childhood asthma; levels of these PAHs were correlated with asthma related biomarkers including IgE, resistin, GMCSF and IFN-γ as well as IL-4, IL-5, IL-8 and IL-10 cytokines.
conclusionsThis data highlight the pivotal role of specific PAHs in childhood asthma.
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