ArticleMolecular brain2013
Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs.
Article in Molecular brain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Associative memory neurons are recruited in PFC-centered circuits to encode schizophrenia-like behavior by dopaminergic receptor-II.Molecular psychiatry · 2026Article
- [Neuronal plasticity changes in the central amygdala and prelimbic cortex network in mice with chronic unpredictable mild stress-induced depression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation.Communications biology · 2024Article
- Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory.International journal of molecular sciences · 2024Article
- Article
- The interconnection and function of associative memory neurons are upregulated for memory strengthening.Frontiers in neural circuits · 2023Article
- Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.Frontiers in cellular neuroscience · 2021Article
- microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens.The Journal of biological chemistry · 2020Article
- Cell-specific plasticity associated with integrative memory of triple sensory signals in the barrel cortex.Oncotarget · 2018Article
- Activity strengths of cortical glutamatergic and GABAergic neurons are correlated with transgenerational inheritance of learning ability.Oncotarget · 2017Article
- Piriform cortical glutamatergic and GABAergic neurons express coordinated plasticity for whisker-induced odor recall.Oncotarget · 2017Article
- Spike Timing-Dependent Plasticity in the Mouse Barrel Cortex Is Strongly Modulated by Sensory Learning and Depends on Activity of Matrix Metalloproteinase 9.Molecular neurobiology · 2017Article
- Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum.Oncotarget · 2017Article
- PKC and CaMK-II inhibitions coordinately rescue ischemia-induced GABAergic neuron dysfunction.Oncotarget · 2017Article
- GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression.Oncotarget · 2017Article
- Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons.Frontiers in cellular neuroscience · 2017Article
- Coordinated Plasticity among Glutamatergic and GABAergic Neurons and Synapses in the Barrel Cortex Is Correlated to Learning Efficiency.Frontiers in cellular neuroscience · 2017Article
- Synapse Innervation and Associative Memory Cell Are Recruited for Integrative Storage of Whisker and Odor Signals in the Barrel Cortex through miRNA-Mediated Processes.Frontiers in cellular neuroscience · 2017Article
- Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress.Translational psychiatry · 2016Article
- Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis.Journal of neuroinflammation · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of a sensory input causes the hypersensitivity in other modalities. In addition to cross-modal plasticity, the sensory cortices without receiving inputs undergo the plastic changes. It is not clear how the different types of neurons and synapses in the sensory cortex coordinately change after input deficits in order to prevent loss of their functions and to be used for other modalities. We studied this subject in the barrel cortices from whiskers-trimmed mice vs. controls. After whisker trimming for a week, the intrinsic properties of pyramidal neurons and the transmission of excitatory synapses were upregulated in the barrel cortex, but inhibitory neurons and GABAergic synapses were downregulated. The morphological analyses indicated that the number of processes and spines in pyramidal neurons increased, whereas the processes of GABAergic neurons decreased in the barrel cortex. The upregulation of excitatory neurons and the downregulation of inhibitory neurons boost the activity of network neurons in the barrel cortex to be high levels, which prevent the loss of their functions and enhances their sensitivity to sensory inputs. These changes may prepare for attracting the innervations from sensory cortices and/or peripheral nerves for other modalities during cross-modal plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.