ArticlePsychological medicine2013
Sleep deprivation amplifies striatal activation to monetary reward.
Article in Psychological medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Pooled it
- Basal ganglia lateralization in different types of reward.Brain imaging and behavior · 2020Pooled it
- Functional brain alterations in acute sleep deprivation: An activation likelihood estimation meta-analysis.Sleep medicine reviews · 2019Pooled it
- The role of baseline insomnia in moderating the hypnotic properties of quetiapine.Addictive behaviors · 2023Trial
- The Effects of Acute Sleep Curtailment on Salt Taste Measures and Relationships with Energy-Corrected Sodium Intake: A Randomized Cross-Over Trial with Methodology Validation.International journal of environmental research and public health · 2023Trial
- More time awake after sleep onset is linked to reduced ventral striatum response to rewards in youth with anxiety.Journal of child psychology and psychiatry, and allied disciplines · 2023Trial
- Trial
- Neurophysiological differences in the adolescent brain following a single night of restricted sleep - A 7T fMRI study.Developmental cognitive neuroscience · 2018Trial
- Neural Sensitivity to Social Media Use: Implications for Sleep Duration in Adolescents.Journal of sleep research · 2026Article
- Acute Sleep Deprivation in Adolescence Produces Transcriptional Changes in the Orexin System and Regulates Motivation for Reward.Biological psychiatry global open science · 2026Article
- Sleep regulates drug seeking and relapse - a perspective.Molecular psychiatry · 2026Review
- Sleep disturbance is associated with greater subjective and neural negative emotionality in people with alcohol use disorder.Drug and alcohol dependence · 2026Article
- Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders.Biological psychiatry · 2025Review
- Sleep deprivation engages the orexin/hypocretin system to regulate food reward seeking.The international journal of neuropsychopharmacology · 2025Article
- Nucleus accumbens dynamics in food reward seeking and regulation by sleep.Translational psychiatry · 2025Article
- Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors.Journal of mood and anxiety disorders · 2025Article
- Sleep and binge eating in early adolescents: a prospective cohort study.Eating and weight disorders : EWD · 2025Article
- Sleep Loss and Substance Use Disorders: An Issue from Adolescents to Adults.Behavioral sciences (Basel, Switzerland) · 2025Review
- Longitudinal Associations between Future Time Perspective, Sleep Problems, and Depressive Symptoms among Chinese College Students: Between- and within-Person Effects.Journal of youth and adolescence · 2025Article
- Olfactory Epithelium Stimulation Using Rhythmic Nasal Air-Puffs Improves the Cognitive Performance of Individuals with Acute Sleep Deprivation.Brain sciences · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSleep loss produces abnormal increases in reward seeking but the mechanisms underlying this phenomenon are poorly understood. The present study examined the influence of one night of sleep deprivation on neural responses to a monetary reward task in a sample of late adolescents/young adults.
methodUsing a within-subjects crossover design, 27 healthy, right-handed late adolescents/young adults (16 females, 11 males; mean age 23.1 years) underwent functional magnetic resonance imaging (fMRI) following a night of sleep deprivation and following a night of normal sleep. Participants’ recent sleep history was monitored using actigraphy for 1 week prior to each sleep condition.
resultsFollowing sleep deprivation, participants exhibited increased activity in the ventral striatum (VS) and reduced deactivation in the medial prefrontal cortex (mPFC) during the winning of monetary reward, relative to the same task following normal sleep conditions. Shorter total sleep time over the five nights before the sleep-deprived testing condition was associated with reduced deactivation in the mPFC during reward.
conclusionsThese findings support the hypothesis that sleep loss produces aberrant functioning in reward neural circuitry, increasing the salience of positively reinforcing stimuli. Aberrant reward functioning related to insufficient sleep may contribute to the development and maintenance of reward dysfunction-related disorders, such as compulsive gambling, eating, substance abuse and mood disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.