ArticleJournal of natural products2013
Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1).
Article in Journal of natural products, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Natural products as transmission-blocking agents against malaria: a comprehensive review of bioactive compounds and their therapeutic potential.Malaria journal · 2025Review
- Antimalarial Natural Products.Progress in the chemistry of organic natural products · 2022Article
- Antiplasmodial natural products: an update.Malaria journal · 2019Review
- Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor.Scientific reports · 2019Article
- Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities.Journal of natural products · 2019Article
- Antiplasmodial flavanones and a stilbene from Carpha glomerata.Bioorganic & medicinal chemistry letters · 2018Article
- Synthesis and Antimalarial Activity of Mallatojaponin C and Related Compounds.Journal of natural products · 2016Article
- New Antiplasmodial Diterpenes from Gutierrezia sarothrae.Natural product communications · 2016Article
- Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera.Bioorganic & medicinal chemistry · 2016Article
- Neolignans and other metabolites from Ocotea cymosa from the Madagascar rain forest and their biological activities.Journal of natural products · 2015Article
- Methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Enterococcus faecium active dimeric isobutyrylphloroglucinol from Ivesia gordonii.Natural product communications · 2014Article
- Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box.Antimicrobial agents and chemotherapy · 2014Article
- Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds.Bioorganic & medicinal chemistry · 2014Article
- A new bioactive diterpene glycoside from Molinaea retusa from the Madagascar dry forest.Natural product communications · 2013Article
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Authors and funding
12 authors.
Funding
Abstract
Bioassay-guided fractionation of an ethanol extract of the leaves and inflorescence of Mallotus oppositifolius collected in Madagascar led to the isolation of the two new bioactive dimeric phloroglucinols mallotojaponins B (1) and C (2), together with the known mallotophenone (3). The structures of the new compounds were determined on the basis of spectroscopic evidence, including their 1D- and 2D-NMR spectra, mass spectrometry, and an X-ray crystal structure. Compounds 1 and 2 showed potent antimalarial activity against chloroquine-resistant Plasmodium falciparum, with IC50 values of 0.75 ± 0.30 and 0.14 ± 0.04 μM, while 3 was inactive in this assay. Compounds 1-3 also displayed strong antiproliferative activity against the A2780 human ovarian cancer cell line (IC50 1.10 ± 0.05, 1.3 ± 0.1 and 6.3 ± 0.4 μM, respectively).
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