ArticleJournal of clinical and diagnostic research : JCDR2012
The role of serum protein electrophoresis in the detection of multiple myeloma: an experience of a corporate hospital.
Article in Journal of clinical and diagnostic research : JCDR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Pulmonary plasma cell disorders: histopathology, diagnosis, and clinical perspectives.Virchows Archiv : an international journal of pathology · 2025Review
- Relevance of Prescribing Serum Immunofixation Electrophoresis in the Diagnosis of Monoclonal Gammopathies.Cureus · 2025Article
- Mitigating Aflatoxin BProbiotics and antimicrobial proteins · 2025Article
- Article
- Unraveling the Possibilities of Monoclonal Protein Migration, Identification, and Characterization in SPEP on Capillary Zone Electrophoresis.Journal of laboratory physicians · 2022Article
- Dual detection high-speed capillary electrophoresis for simultaneous serum protein analysis and immunoassays.Scientific reports · 2022Article
- Significance of Serum Protein Electrophoresis in the Detection of Multiple Myeloma: A Diagnostic Interpretation of Patients with Varied Immunoglobulins.International journal of preventive medicine · 2021Article
- Article
- Development of a clinical diagnostic tool to differentiate multiple myeloma from bone metastasis in patients with destructive bone lesions (MM-BM DDx).BMC family practice · 2020Article
- Article
- The impact on early diagnosis and survival outcome of M-protein screening-driven diagnostic approach to multiple myeloma in China: a cohort study.Journal of Cancer · 2019Article
- [Serum protein electrophoresis: study of 410 electrophoretic profiles].The Pan African medical journal · 2019Article
- Role of Dietary Crocin in In Vivo Melanoma Tumor RemissionAsian Pacific journal of cancer prevention : APJCP · 2017Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple Myeloma (M.M) is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells, secreting abnormal immunoglobulin causing monoclonal gammopathy which can be detected by the presence of M protein in serum and urine electrophoresis.
aimTo detect and quantify monoclonal gammopathy in suspected cases of multiple myeloma and to differentiate them from benign conditions, because of the vast difference between their prognosis and management.
methodSerum samples from 150 suspected cases of M.M were subjected to serum protein electrophoresis on cellulose acetate strip. M band detected visually and estimation of M protein was done by densitometer. Bone Marrow biopsy and clinical profile were correlated in M band positive cases.
resultOut of 150 cases 10.66% cases had monoclonal gammopathy. Ten percent cases were diagnosed to be multiple myeloma and one case was found to be Monoclonal gammopathy of undetermined significance.
conclusionSPEP is an easy to perform laboratory test which can be used for detection and quantification of monoclonal gammopathy and should be recommended as preliminary test for suspected cases of multiple myeloma. MGUS must be differentiated from M.M, as management and prognosis of these two cases is totally different.
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