ArticlePloS one2012
Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity.PLoS genetics · 2026Article
- Credit to the Fruit Fly: How the Tiny Insect Lights Up Our Understanding of Human Disease.Insects · 2026Review
- Epigenetic Regulation in Drosophila Tumor Models.Advances in experimental medicine and biology · 2025Review
- Article
- Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.Developmental biology · 2021Review
- Hox genes limit germ cell formation in the short germ insectProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker.Nature communications · 2019Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.Scientific reports · 2017Article
- Article
- Stem cell autotomy and niche interaction in different systems.World journal of stem cells · 2015Review
- Epigenetic regulation of germ cells-remember or forget?Current opinion in genetics & development · 2015Review
- Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster.Cell reports · 2014Article
- BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.Nature cell biology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Adult stem cells are essential for the proper function of many tissues, yet the mechanisms that maintain the proper identity and regulate proliferative capacity in stem cell lineages are not well understood. Polycomb group (PcG) proteins are transcriptional repressors that have recently emerged as important regulators of stem cell maintenance and differentiation. Here we describe the role of Polycomb Repressive Complex 1 (PRC1) genes Posterior sex combs (Psc) and Suppressor of zeste two (Su(z)2) in restricting the proliferation and maintaining the identity of the Cyst Stem Cell (CySC) lineage in the Drosophila testis. In contrast, Psc and Su(z)2 seem to be dispensable for both germline stem cell (GSC) maintenance and germ cell development. We show that loss of Psc and Su(z)2 function in the CySC lineage results in the formation of aggregates of mutant cells that proliferate abnormally, and display abnormal somatic identity correlated with derepression of the Hox gene Abdominal-B. Furthermore, we show that tumorigenesis in the CySC lineage interferes non-cell autonomously with maintenance of GSCs most likely by displacing them from their niche.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.