ArticlePloS one2012
Correlation of viral loads with HCV genotypes: higher levels of virus were revealed among blood donors infected with 6a strains.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- HCV 6a was expanding and became the predominant subtype among blood donors between 2004 and 2019 in Guangdong, China.Virologica Sinica · 2022Article
- Association of HCV genotype with viral load among Iranian blood donors: a penalized logistic regression.Medical journal of the Islamic Republic of Iran · 2019Article
- Assessment of HCV genotypes in Yunnan Province of Southwest China.Virus genes · 2017Article
- Hepatitis C Virus in mainland China with an emphasis on genotype and subtype distribution.Virology journal · 2017Review
- Article
- Factors associated with hepatitis C virus RNA levels in early chronic infection: the InC3 study.Journal of viral hepatitis · 2015Article
- HLA-B alleles B*15:01 and B*15:02: opposite association with hepatitis C virus infection in Chinese voluntary blood donors.Intervirology · 2015Article
- Increased prevalence of hepatitis C virus subtype 6a in China: a comparison between 2004-2007 and 2008-2011.Archives of virology · 2014Article
- Hepatitis C virus genotype 6: virology, epidemiology, genetic variation and clinical implication.World journal of gastroenterology · 2014Review
- Article
- Article
- One-step real-time PCR assay for detection and quantification of RNA HCV to monitor patients under treatment in Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
- Association of genotypes with viral load and biochemical markers in HCV-infected Sindhi patients.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundBoth HCV genotypes and viral loads are predictors of therapeutic outcomes among patients treated with α-interferon plus ribavirin; however, such correlation has only been studied for genotypes 1, 2, and 3 but not for genotype 6. METHODOLOGY/
findings299 voluntary blood donors were recruited who were HCV viremic. Their mean age was 31.8; the male/female ratio was 3.82 (225/59). The viral loads of HCV were measured using the COBAS AmpliPrep/COBAS TaqMan test (CAP/CTM) while HCV genotypes were determined by direct sequencing the partial NS5B region. HCV genotypes 1, 2, 3, and 6 were determined in 48.9%, 8.7%, 12.3%, and 30.1% of the donors, respectively, and the levels of mean viral loads in genotype 1 and 6 significantly higher than that of 2 and 3 (P<0.001). As a whole, the viral loads in male donors were higher than in female (P = 0.006). Moreover, the donors' gender and HCV genotypes are independently correlated with the measured viral loads.
conclusionHCV genotype 1 and 6 had significantly higher viral loads than genotype 2 and 3.
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