ArticlePloS one2012
Transforming growth factor-β, macrophage colony-stimulating factor and C-reactive protein levels correlate with CD14(high)CD16+ monocyte induction and activation in trauma patients.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Circulating Interleukin-6 and CD16 positive monocytes increase following angioplasty of an arteriovenous fistula.Scientific reports · 2022Trial
- Association of small dense LDL serum levels and circulating monocyte subsets in stable coronary artery disease.PloS one · 2015Trial
- Article
- Immune cell dynamics, cytokines, and extracellular vesicles in systemic inflammatory response syndrome (SIRS): a multiparametric analysis.Journal of translational medicine · 2025Article
- Association of White Blood Cell Subtypes and Derived Ratios with a Mortality Outcome in Adult Patients with Polytrauma.Healthcare (Basel, Switzerland) · 2022Article
- C-Reactive Protein: Marker of risk for post-traumatic stress disorder and its potential for a mechanistic role in trauma response and recovery.The European journal of neuroscience · 2022Review
- C-Reactive Protein: Friend or Foe? Phylogeny From Heavy Metals to Modified Lipoproteins and SARS-CoV-2.Frontiers in cardiovascular medicine · 2022Review
- The Role of the Inflammatory Response in Mediating Functional Recovery Following Composite Tissue Injuries.International journal of molecular sciences · 2021Review
- The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery.iScience · 2021Article
- Severe Traumatic Injury Induces Phenotypic and Functional Changes of Neutrophils and Monocytes.Journal of clinical medicine · 2021Article
- Differences in monocyte subsets are associated with short-term survival in patients with septic shock.Journal of cellular and molecular medicine · 2020Observational
- Macrophages play an essential role in trauma-induced sterile inflammation and tissue repair.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Review
- The diversity of myeloid immune cells shaping wound repair and fibrosis in the lung.Regeneration (Oxford, England) · 2018Review
- Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study.PLoS medicine · 2017Article
- Accelerating skin wound healing by M-CSF through generating SSEA-1 and -3 stem cells in the injured sites.Scientific reports · 2016Article
- Pharmacological adjuncts to stop bleeding: options and effectiveness.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016Review
- Monocyte Subsets and Inflammatory Cytokines in Acute Decompensated Heart Failure.Journal of cardiac failure · 2016Article
- An FcγRIIa polymorphism with decreased C-reactive protein binding is associated with sepsis and decreased monocyte HLA-DR expression in trauma patients.The journal of trauma and acute care surgery · 2015Observational
- Circulating levels of platelet α-granule cytokines in trauma patients.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Observational
- Transcriptome analysis in patients with chronic kidney disease on hemodialysis disclosing a key role for CD16+CX3CR1+ monocytes.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Severe injury remains a leading cause of death and morbidity in patients under 40, with the number of annual trauma-related deaths approaching 160,000 in the United States. Patients who survive the initial trauma and post-traumatic resuscitation are at risk for immune dysregulation, which contributes to late mortality and accounts for approximately 20% of deaths after traumatic injury. This post-traumatic immunosuppressed state has been attributed to over-expression of anti-inflammatory mediators in an effort to restore host homeostasis. We measured a panel of monocyte markers and cytokines in 50 severely injured trauma patients for 3 days following admission. We made the novel observation that the subpopulation of monocytes expressing high levels of CD14 and CD16 was expanded in the majority of patients. These cells also expressed CD163 consistent with differentiation into alternatively activated macrophages with potential regulatory or wound-healing activity. We examined factors in trauma plasma that may contribute to the generation and activation of these cells. The percentage of CD14(high)CD16(+) monocytes after trauma correlated strongly with plasma C-reactive protein (CRP) transforming growth factor-β (TGF-β), and macrophage colony-stimulating factor (M-CSF) levels. We demonstrate a role for TGF-β and M-CSF, but not CRP in generating these cells using monocytes from healthy volunteers incubated with plasma from trauma patients. CD16 is a receptor for CRP and IgG, and we showed that monocytes differentiated to the CD14(high)CD16(+) phenotype produced anti-inflammatory cytokines in response to acute phase concentrations of CRP. The role of these cells in immunosuppression following trauma is an area of ongoing investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.