ArticlePloS one2012
Metabolic responses of primary and transformed cells to intracellular Listeria monocytogenes.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Trehalose metabolism and its impact on PrfA activity inJournal of bacteriology · 2026Article
- Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.Nature communications · 2025Article
- Dual Isotopologue Profiling of Bacterial Pathogens and their Host Cells: Metabolic Adaptation of Human Macrophages and Fallopian Tube Cells to IntracellularACS chemical biology · 2025Article
- Article
- Bacterial Lipoproteins Shift Cellular Metabolism to Glycolysis in Macrophages Causing Bone Erosion.Microbiology spectrum · 2023Article
- Immunometabolic crosstalk during bacterial infection.Nature microbiology · 2022Review
- Article
- Identification of genetic elements required forFrontiers in microbiology · 2022Article
- Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling.Cell reports · 2021Article
- Diversity of energy metabolism in immune responses regulated by micro-organisms and dietary nutrition.International immunology · 2020Review
- Immunometabolism of Macrophages in Bacterial Infections.Frontiers in cellular and infection microbiology · 2020Review
- Persistence of Intracellular Bacterial Pathogens-With a Focus on the Metabolic Perspective.Frontiers in cellular and infection microbiology · 2020Review
- Cellular Microbiology: The metabolic interface between host cell and pathogen.Cellular microbiology · 2019Review
- Central metabolic interactions of immune cells and microbes: prospects for defeating infections.EMBO reports · 2019Review
- Metabolism of the Gram-Positive Bacterial PathogenMicrobiology spectrum · 2019Review
- Immunometabolism at the interface between macrophages and pathogens.Nature reviews. Immunology · 2019Review
- Interaction between Intracellular Bacterial Pathogens and Host Cell Mitochondria.Microbiology spectrum · 2019Review
- How Viral and Intracellular Bacterial Pathogens Reprogram the Metabolism of Host Cells to Allow Their Intracellular Replication.Frontiers in cellular and infection microbiology · 2019Review
- The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella.Nature communications · 2017Article
- Listeria monocytogenes cytosolic metabolism promotes replication, survival, and evasion of innate immunity.Cellular microbiology · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolic response of host cells, in particular of primary mammalian cells, to bacterial infections is poorly understood. Here, we compare the carbon metabolism of primary mouse macrophages and of established J774A.1 cells upon Listeria monocytogenes infection using (13)C-labelled glucose or glutamine as carbon tracers. The (13)C-profiles of protein-derived amino acids from labelled host cells and intracellular L. monocytogenes identified active metabolic pathways in the different cell types. In the primary cells, infection with live L. monocytogenes increased glycolytic activity and enhanced flux of pyruvate into the TCA cycle via pyruvate dehydrogenase and pyruvate carboxylase, while in J774A.1 cells the already high glycolytic and glutaminolytic activities hardly changed upon infection. The carbon metabolism of intracellular L. monocytogenes was similar in both host cells. Taken together, the data suggest that efficient listerial replication in the cytosol of the host cells mainly depends on the glycolytic activity of the hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.