ArticlePloS one2012
The h-current in the substantia Nigra pars compacta neurons: a re-examination.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
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- Muscarinic receptor activation preferentially inhibits rebound in vulnerable dopaminergic neurons.bioRxiv : the preprint server for biology · 2024Article
- Role of HCN channels in the functions of basal ganglia and Parkinson's disease.Cellular and molecular life sciences : CMLS · 2024Review
- The Neuroprotective Effects of the CB2 Agonist GW842166x in the 6-OHDA Mouse Model of Parkinson's Disease.Cells · 2021Article
- Enhanced Activation of HCN Channels Reduces Excitability and Spike-Timing Regularity in Maturing Vestibular Afferent Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons.Stem cells translational medicine · 2019Article
- Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: An Emerging Role in Neurodegenerative Diseases.Frontiers in molecular neuroscience · 2019Review
- The Effects of Quinine on Neurophysiological Properties of Dopaminergic Neurons.Neurotoxicity research · 2018Article
- Cocaine sensitization increases subthreshold activity in dopamine neurons from the ventral tegmental area.Journal of neurophysiology · 2017Article
- Purkinje cell intrinsic excitability increases after synaptic long term depression.Journal of neurophysiology · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The properties of the hyperpolarization-activated cation current (I(h)) were investigated in rat substantia nigra - pars compacta (SNc) principal neurons using patch-clamp recordings in thin slices. A reliable identification of single dopaminergic neurons was made possible by the use of a transgenic line of mice expressing eGFP under the tyrosine hydroxylase promoter. The effects of temperature and different protocols on the I(h) kinetics showed that, at 37°C and minimizing the disturbance of the intracellular milieu with perforated patch, this current actually activates at potentials more positive than what is generally indicated, with a half-activation potential of -77.05 mV and with a significant level of opening already at rest, thereby substantially contributing to the control of membrane potential, and ultimately playing a relevant function in the regulation of the cell excitability. The implications of the known influence of intracellular cAMP levels on I(h) amplitude and kinetics were examined. The direct application of neurotransmitters (DA, 5-HT and noradrenaline) physiologically released onto SNc neurons and known to act on metabotropic receptors coupled to the cAMP pathway modify the I(h) amplitude. Here, we show that direct activation of dopaminergic and of 5-HT receptors results in I(h) inhibition of SNc DA cells, whereas noradrenaline has the opposite effect. Together, these data suggest that the modulation of I(h) by endogenously released neurotransmitters acting on metabotropic receptors -mainly but not exclusively linked to the cAMP pathway- could contribute significantly to the control of SNc neuron excitability.
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