ArticlePloS one2012
Identification and comparative analysis of ncRNAs in human, mouse and zebrafish indicate a conserved role in regulation of genes expressed in brain.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
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- Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice.BMC genomics · 2019Article
- Long noncoding RNAs are associated with metabolic and cellular processes in the jejunum mucosa of pre-weaning calves in response to different diets.Oncotarget · 2018Article
- The Long Noncoding RNA Transcriptome ofG3 (Bethesda, Md.) · 2017Article
- Transcriptional regulation of long-term potentiation.Neurogenetics · 2016Review
- Identification and Classification of New Transcripts in Dorper and Small-Tailed Han Sheep Skeletal Muscle Transcriptomes.PloS one · 2016Article
- Generation of a de novo transcriptome from equine lamellar tissue.BMC genomics · 2015Article
- Genome wide discovery of long intergenic non-coding RNAs in Diamondback moth (Plutella xylostella) and their expression in insecticide resistant strains.Scientific reports · 2015Article
- Identification of 4438 novel lincRNAs involved in mouse pre-implantation embryonic development.Molecular genetics and genomics : MGG · 2015Article
- Identification and characterization of long intergenic non-coding RNAs related to mouse liver development.Molecular genetics and genomics : MGG · 2014Article
- Identification and functional analysis of long non-coding RNAs in mouse cleavage stage embryonic development based on single cell transcriptome data.BMC genomics · 2014Article
- Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications.Trends in genetics : TIG · 2014Review
- Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease.Frontiers in genetics · 2014Review
- Identification of novel transcripts and noncoding RNAs in bovine skin by deep next generation sequencing.BMC genomics · 2013Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ncRNAs (non-coding RNAs), in particular long ncRNAs, represent a significant proportion of the vertebrate transcriptome and probably regulate many biological processes. We used publically available ESTs (Expressed Sequence Tags) from human, mouse and zebrafish and a previously published analysis pipeline to annotate and analyze the vertebrate non-protein-coding transcriptome. Comparative analysis confirmed some previously described features of intergenic ncRNAs, such as a positionally biased distribution with respect to regulatory or development related protein-coding genes, and weak but clear sequence conservation across species. Significantly, comparative analysis of developmental and regulatory genes proximate to long ncRNAs indicated that the only conserved relationship of these genes to neighbor long ncRNAs was with respect to genes expressed in human brain, suggesting a conserved, ncRNA cis-regulatory network in vertebrate nervous system development. Most of the relationships between long ncRNAs and proximate coding genes were not conserved, providing evidence for the rapid evolution of species-specific gene associated long ncRNAs. We have reconstructed and annotated over 130,000 long ncRNAs in these three species, providing a significantly expanded number of candidates for functional testing by the research community.
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