ArticlePloS one2012
The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Relationship between Pituitary Gland and Stem Cell in the Aspect of Hormone Production and Disease Prevention: A Narrative Review.Endocrine, metabolic & immune disorders drug targets · 2025Review
- gBLUP-GWAS identifies candidate genes, signaling pathways, and putative functional polymorphisms for age at puberty in gilts.Journal of animal science · 2023Article
- Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2021Article
- LncRNA FOXD1-AS1 acts as a potential oncogenic biomarker in glioma.CNS neuroscience & therapeutics · 2020Article
- The multisystemic functions of FOXD1 in development and disease.Journal of molecular medicine (Berlin, Germany) · 2018Review
- Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes.Developmental biology · 2018Article
- Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways.Molecular and cellular endocrinology · 2017Review
- FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells.Cancer research · 2016Article
- β-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis.BMC developmental biology · 2016Article
- Article
- Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors.Molecular and cellular endocrinology · 2014Review
- Pituitary gland development and disease: from stem cell to hormone production.Current topics in developmental biology · 2013Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pituitary gland regulates numerous physiological functions including growth, reproduction, temperature and metabolic homeostasis, lactation, and response to stress. Pituitary organogenesis is dependent on signaling factors that are produced in and around the developing pituitary. The studies described in this report reveal that the forkhead transcription factor, Foxd1, is not expressed in the developing mouse pituitary gland, but rather in the mesenchyme surrounding the pituitary gland, which is an essential source of signaling factors that regulate pituitary organogenesis. Loss of Foxd1 causes a morphological defect in which the anterior lobe of the pituitary gland protrudes through the cartilage plate that is developing ventral to the pituitary at embryonic days (e)14.5, e16.5, and e18.5. The number of proliferating pituitary cells is increased at e14.5 and e16.5. Loss of Foxd1 also results in significantly decreased levels of Lhb expression at e18.5. This decrease in Lhb expression does not appear to be due to a change in the number of gonadotrope cells in the pituitary gland. Previous studies have shown that loss of the LIM homeodomain factor, Lhx3, which is activated by the FGF signaling pathway, results in loss of LH production. Although there is a difference in Lhb expression in Foxd1 null mice, the expression pattern of LHX3 is not altered in Foxd1 null mice. These studies suggest that Foxd1 is indirectly required for normal Lhb expression and cartilage formation.
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